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应激性心肌病:肝移植受者中一种酷似急性心肌梗死的心脏综合征

Takotsubo Cardiomyopathy: A Cardiac Syndrome Mimicking Acute Myocardial Infarction in a Liver Transplant Recipient.

作者信息

Anders Maria M, Comignani Pablo D, Couce Rocio, Prini Nadia, Zerega Alina R, Santopinto Mariano, Devetach Gustavo, Quinonez Emilio G, Goldaracena Nicolas, McCormack Lucas, Mastai Ricardo C

机构信息

Liver Transplant Program, Hospital Aleman, Buenos Aires, Argentina.

出版信息

Cardiol Res. 2011 Apr;2(2):82-85. doi: 10.4021/cr35e. Epub 2011 Mar 25.

DOI:10.4021/cr35e
PMID:28348667
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5358193/
Abstract

Takotsubo cardiomyopathy (TTC) is a rare clinical syndrome defined as a profound but reversible left ventricular dysfunction in the absence of coronary artery disease. We describe the clinical features and management of TC manifesting in the postoperative period in a patient undergoing liver transplantation. Two days after surgery, the patient developed clinical features of acute myocardial infarction. Ecochardiography revealed hypokinesis of the left ventricle. Coronary angiography revealed normal arteries without any stenosis or obstruction. The patient required vasopressor and inotropic support. The placement of intra-aortic balloon pump had a beneficial effect on the management of heart failure. The patient had a complete recovery of cardiac function 40 days after surgery. TC is a possible occurrence after liver transplant. Awareness of this condition is essential as early diagnosis and prompt management can save the patient's life.

摘要

应激性心肌病(TTC)是一种罕见的临床综合征,定义为在无冠状动脉疾病的情况下出现严重但可逆的左心室功能障碍。我们描述了一名接受肝移植患者术后出现的应激性心肌病的临床特征及治疗情况。术后两天,患者出现急性心肌梗死的临床症状。超声心动图显示左心室运动减弱。冠状动脉造影显示动脉正常,无任何狭窄或阻塞。患者需要血管加压药和正性肌力药物支持。主动脉内球囊泵的置入对心力衰竭的治疗有有益作用。患者术后40天心脏功能完全恢复。应激性心肌病是肝移植后可能出现的情况。认识到这种病症至关重要,因为早期诊断和及时治疗可挽救患者生命。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c483/5358193/7e9910607e55/cr-02-082-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c483/5358193/0e919ed1567c/cr-02-082-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c483/5358193/7e9910607e55/cr-02-082-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c483/5358193/0e919ed1567c/cr-02-082-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c483/5358193/7e9910607e55/cr-02-082-g002.jpg

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引用本文的文献

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Perioperative Stress-Induced (Takotsubo) Cardiomyopathy in Liver Transplant Recipients.肝移植受者围手术期应激性(应激性心肌病)心肌病
J Crit Care Med (Targu Mures). 2018 Apr 1;4(2):56-63. doi: 10.2478/jccm-2018-0006. eCollection 2018 Apr.
2
Does autonomic re-innervation cause Takotsubo syndrome in a transplanted heart? Comment on: "Takotsubo cardiomyopathy in a young adult with transplanted heart: what happened to denervation?" by Chinali et al.自主神经再支配会导致移植心脏发生应激性心肌病吗?对Chinali等人所著的《年轻成年移植心脏患者的应激性心肌病:去神经支配后发生了什么?》的评论
ESC Heart Fail. 2018 Dec;5(6):1197-1198. doi: 10.1002/ehf2.12318. Epub 2018 Aug 14.
3

本文引用的文献

1
Intraoperative left ventricular apical ballooning: transient Takotsubo cardiomyopathy during orthotopic liver transplantation.术中左心室心尖部气球样变:原位肝移植术中的短暂性应激性心肌病
J Cardiothorac Vasc Anesth. 2008 Jun;22(3):442-5. doi: 10.1053/j.jvca.2007.11.015. Epub 2008 Mar 14.
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Prevalence of Tako-Tsubo Syndrome among patients with suspicion of acute coronary syndrome referred to our centre.转诊至我们中心的疑似急性冠状动脉综合征患者中应激性心肌病的患病率。
Int J Cardiol. 2009 May 15;134(2):255-9. doi: 10.1016/j.ijcard.2007.12.104. Epub 2008 Apr 14.
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Apical ballooning syndrome (Tako-Tsubo or stress cardiomyopathy): a mimic of acute myocardial infarction.
Mending a Broken Heart: Treatment of Stress-Induced Heart Failure after Solid Organ Transplantation.
修复破碎的心:实体器官移植后应激性心力衰竭的治疗
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Am Heart J. 2008 Mar;155(3):408-17. doi: 10.1016/j.ahj.2007.11.008. Epub 2008 Jan 31.
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Takotsubo cardiomyopathy.应激性心肌病
Heart Lung. 2008 Jan-Feb;37(1):1-7. doi: 10.1016/j.hrtlng.2006.12.003.
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A pathophysiologic study of tako-tsubo cardiomyopathy with F-18 fluorodeoxyglucose positron emission tomography.采用F-18氟脱氧葡萄糖正电子发射断层扫描术对应激性心肌病进行的病理生理学研究
Eur Heart J. 2007 Nov;28(21):2598-604. doi: 10.1093/eurheartj/ehm401. Epub 2007 Oct 7.
6
Transient left ventricular apical ballooning syndrome (Takotsubo cardiomyopathy) following orthotopic liver transplantation.原位肝移植术后的短暂性左心室心尖气球样变综合征(应激性心肌病)
Liver Transpl. 2007 Sep;13(9):1343-5. doi: 10.1002/lt.21169.
7
Myocardial perfusion in apical ballooning syndrome correlate of myocardial injury.心尖气球样综合征的心肌灌注与心肌损伤的相关性。
Am Heart J. 2006 Sep;152(3):469.e9-13. doi: 10.1016/j.ahj.2006.06.007.
8
Acute impairment of regional myocardial glucose uptake in the apical ballooning (takotsubo) syndrome.心尖球囊样变(应激性心肌病)综合征中局部心肌葡萄糖摄取的急性受损
J Nucl Cardiol. 2006 Mar-Apr;13(2):244-50. doi: 10.1007/BF02971249.
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Neurohumoral features of myocardial stunning due to sudden emotional stress.突发情绪应激所致心肌顿抑的神经体液特征
N Engl J Med. 2005 Feb 10;352(6):539-48. doi: 10.1056/NEJMoa043046.
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Systematic review: transient left ventricular apical ballooning: a syndrome that mimics ST-segment elevation myocardial infarction.系统评价:短暂性左心室心尖气球样变:一种酷似ST段抬高型心肌梗死的综合征
Ann Intern Med. 2004 Dec 7;141(11):858-65. doi: 10.7326/0003-4819-141-11-200412070-00010.