端粒与雌激素：动脉粥样硬化发病机制中的不良关联
Telomeres and Estrogens: The Unholy Nexus in Pathogenesis of Atherosclerosis.
作者信息
Sameer Aga Syed, Nissar Saniya, Aziz Ruqaya
机构信息
Department of Biochemistry, Sher-I-Kashmir Institute of Medical Sciences Associated Medical College, Bemina, Srinagar, Kashmir 190018, India.
Department of Biochemistry, Kashmir University, Hazratbal, Srinagar, Kashmir 190006, India.
出版信息
Cardiol Res. 2014 Aug;5(3-4):85-90. doi: 10.14740/cr335e. Epub 2014 Jul 20.
Abstract
Atherosclerosis (AS) is a complex inflammatory process and is categorized as a multifactorial disease involving the interplay of genetic and environmental factors. There are many factors which play role in predisposition and development of AS. In this review we have tried to address the basic pathophysiology of AS lesions and the role played by two important factors - telomeres and estrogens in the development of this disease.
摘要
动脉粥样硬化（AS）是一个复杂的炎症过程，被归类为一种涉及遗传和环境因素相互作用的多因素疾病。有许多因素在AS的易感性和发展中起作用。在这篇综述中，我们试图阐述AS病变的基本病理生理学以及两个重要因素——端粒和雌激素在该疾病发展中所起的作用。
相似文献
1
Telomeres and Estrogens: The Unholy Nexus in Pathogenesis of Atherosclerosis.端粒与雌激素：动脉粥样硬化发病机制中的不良关联
Cardiol Res. 2014 Aug;5(3-4):85-90. doi: 10.14740/cr335e. Epub 2014 Jul 20.
2
Lipids and cardiovascular disease: do the findings and therapy apply equally to men and women?脂质与心血管疾病：这些研究结果及治疗方法对男性和女性同样适用吗？
Womens Health Issues. 1992 Summer;2(2):102-11; discussion 111-3. doi: 10.1016/s1049-3867(05)80278-6.
3
Pathogenesis of atherosclerosis.
Maturitas. 1996 May;23 Suppl:S47-9. doi: 10.1016/0378-5122(96)01011-0.
4
The role of dietary oxidized cholesterol and oxidized fatty acids in the development of atherosclerosis.膳食氧化胆固醇和氧化脂肪酸在动脉粥样硬化发展中的作用。
Mol Nutr Food Res. 2005 Nov;49(11):1075-82. doi: 10.1002/mnfr.200500063.
5
Potential role of the interaction between equine estrogens, low-density lipoprotein (LDL) and high-density lipoprotein (HDL) in the prevention of coronary heart and neurodegenerative diseases in postmenopausal women.马雌激素、低密度脂蛋白（LDL）和高密度脂蛋白（HDL）之间的相互作用在预防绝经后女性冠心病和神经退行性疾病中的潜在作用。
Lipids Health Dis. 2003 Jun 20;2:4. doi: 10.1186/1476-511X-2-4.
6
[The effects of androgens and other sex hormones on serum lipoproteins].[雄激素及其他性激素对血清脂蛋白的影响]
Lijec Vjesn. 1996 Mar;118 Suppl 1:33-7.
7
[Sex hormones and metabolism of lipoproteins].[性激素与脂蛋白代谢]
Ann Endocrinol (Paris). 1983 Jan-Mar;44(1):59-65.
8
9
[Lipids and atherosclerosis].
Wiad Lek. 1996;49(7-12):153-8.
10
Atherogenesis: why women live longer than men.动脉粥样硬化形成：为何女性比男性寿命更长。
Geriatrics. 1985 Jan;40(1):42-51, 54.
引用本文的文献
1
The correlation between serum MHR and NLR and the severity of coronary lesions in NSTE-ACS patients of different genders.不同性别非ST段抬高型急性冠状动脉综合征（NSTE-ACS）患者血清MHR和NLR与冠状动脉病变严重程度的相关性
Front Cardiovasc Med. 2025 Jan 14;11:1469730. doi: 10.3389/fcvm.2024.1469730. eCollection 2024.
2
Aging-Induced Impairment of Vascular Function: Mitochondrial Redox Contributions and Physiological/Clinical Implications.衰老导致的血管功能障碍：线粒体氧化还原贡献及生理/临床意义。
Antioxid Redox Signal. 2021 Oct 20;35(12):974-1015. doi: 10.1089/ars.2021.0031. Epub 2021 Sep 17.
3
Expression of Telomeric Repeat-Containing RNA Decreases in Sarcopenia and Increases after Exercise and Nutrition Intervention.端粒重复 RNA 的表达在肌肉减少症中降低，在运动和营养干预后增加。
Nutrients. 2020 Dec 8;12(12):3766. doi: 10.3390/nu12123766.
4
Significant SNPs Related to Telomere Length and Hepatocellular Carcinoma Risk in Chronic Hepatitis B Carriers.慢性乙型肝炎携带者中与端粒长度及肝细胞癌风险相关的重要单核苷酸多态性
Asian Pac J Cancer Prev. 2018 Mar 27;19(3):585-590. doi: 10.22034/APJCP.2018.19.3.585.
本文引用的文献
1
Role of estrogen in angiogenesis in cardiovascular diseases.雌激素在心血管疾病血管生成中的作用。
J Geriatr Cardiol. 2013 Dec;10(4):377-82. doi: 10.3969/j.issn.1671-5411.2013.04.008.
2
Tissue factor pathway inhibitor blocks angiogenesis via its carboxyl terminus.组织因子途径抑制剂通过其羧基末端阻断血管生成。
Arterioscler Thromb Vasc Biol. 2012 Mar;32(3):704-11. doi: 10.1161/ATVBAHA.111.243733. Epub 2012 Jan 5.
3
Estrogen signaling and cardiovascular disease.雌激素信号与心血管疾病。
Circ Res. 2011 Sep 2;109(6):687-96. doi: 10.1161/CIRCRESAHA.110.236687.
4
Estrogen receptor activation and cardioprotection in ischemia reperfusion injury.雌激素受体激活与缺血再灌注损伤的心脏保护。
Trends Cardiovasc Med. 2010 Apr;20(3):73-8. doi: 10.1016/j.tcm.2010.05.001.
5
Pathogenesis of atherosclerosis: A multifactorial process.动脉粥样硬化的发病机制：一个多因素过程。
Exp Clin Cardiol. 2002 Spring;7(1):40-53.
6
Estrogen receptor-beta activation results in S-nitrosylation of proteins involved in cardioprotection.雌激素受体-β激活导致参与心脏保护的蛋白质发生S-亚硝基化。
Circulation. 2009 Jul 21;120(3):245-54. doi: 10.1161/CIRCULATIONAHA.109.868729. Epub 2009 Jul 6.
7
[Estradiol promote myocardial angiogenesis in a rat model of acute myocardial infarction through estrogen receptors].
Sichuan Da Xue Xue Bao Yi Xue Ban. 2008 May;39(3):398-401.
8
Estrogen receptors alpha and beta mediate distinct pathways of vascular gene expression, including genes involved in mitochondrial electron transport and generation of reactive oxygen species.雌激素受体α和β介导血管基因表达的不同途径，包括参与线粒体电子传递和活性氧生成的基因。
Mol Endocrinol. 2007 Jun;21(6):1281-96. doi: 10.1210/me.2006-0497. Epub 2007 Mar 20.
9
Telomere biology and cardiovascular disease.端粒生物学与心血管疾病
Circ Res. 2006 Nov 24;99(11):1167-80. doi: 10.1161/01.RES.0000251281.00845.18.
10
Estrogens, selective estrogen receptor modulators, and a selective estrogen receptor down-regulator inhibit endothelial production of tissue factor pathway inhibitor 1.雌激素、选择性雌激素受体调节剂及一种选择性雌激素受体下调剂可抑制内皮细胞组织因子途径抑制物-1的生成。
BMC Cardiovasc Disord. 2006 Oct 9;6:40. doi: 10.1186/1471-2261-6-40.
Zotero 插件