巴西里约热内卢一名与阿尔茨海默病患者相关的罕见肺炎病例。
: a rare case of pneumonia associated with an Alzheimer patient in Rio de Janeiro, Brazil.
作者信息
Lima Carla Ormundo Gonçalves Ximenes, da Rocha Vinicius Magno, Ferreira Eliane de Oliveira, Filho Joaquim Santos, Serradas Lucia Rodrigues, Silva Rodrigo Otávio Silveira, Lobato Francisco Carlos Faria, Domingues Regina Maria Cavalcanti Pilotto
机构信息
Hospital de Clínicas Rio Mar Barra LTDA , Avenida Candido Portinari, 555. Rio de Janeiro, RJ , Brazil.
Hospital Universitário Gaffrée e Guinle , Rua Mariz e Barros, 755. Rio de Janeiro, RJ , Brazil.
出版信息
JMM Case Rep. 2016 Aug 30;3(4):e005041. doi: 10.1099/jmmcr.0.005041. eCollection 2016 Aug.
INTRODUCTION
is rarely associated with human diseases. Infection is usuallcaused by ingestion of contaminated food, and infant botulism is the most common clinical presentation.
CASE REPORT
Here we report a case of pneumonia by a non-toxigenic strain of in an Alzheimer 70-year-old male with sepsis in Rio de Janeiro, Brazil. The micro-organism was identified by phenotypical tests, mass spectrometry (MALDI-TOF), DNA amplification (PCR) and sequencing of the 16S rRNA gene. Testing for the presence of botulinum F toxin was made using multiplex PCR. Bioassay for a large number of colonies was performed in mice to evaluate the production of any lethal toxin, but the results were negative.
CONCLUSION
To our knowledge, there are no cases of infection reported in Brazil and we highlight the importance of anaerobic lab tests in the standard routine of diagnosis.
引言
很少与人类疾病相关。感染通常由摄入受污染食物引起，婴儿肉毒中毒是最常见的临床表现。
病例报告
我们在此报告一例在巴西里约热内卢一名患有败血症的70岁阿尔茨海默病男性中由非产毒菌株引起的肺炎病例。该微生物通过表型试验、质谱分析（基质辅助激光解吸电离飞行时间质谱）、DNA扩增（聚合酶链反应）以及16S rRNA基因测序进行鉴定。使用多重聚合酶链反应检测肉毒杆菌F毒素的存在。在小鼠中对大量菌落进行生物测定以评估是否产生任何致死毒素，但结果为阴性。
结论
据我们所知，巴西尚未报告过感染病例，我们强调厌氧实验室检测在标准常规诊断中的重要性。
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