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Commentary: Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study).

作者信息

Saba Nabil F

机构信息

Hematology and Medical Oncology, Winship Cancer Institute of Emory University , Atlanta, GA , USA.

出版信息

Front Oncol. 2017 Mar 13;7:31. doi: 10.3389/fonc.2017.00031. eCollection 2017.

DOI:10.3389/fonc.2017.00031
PMID:28348975
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5346538/
Abstract
摘要

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Commentary: Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study).评论：杜利戈图单抗（MEHD7945A）与西妥昔单抗治疗头颈部鳞状细胞癌的随机II期研究（MEHGAN研究）。
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本文引用的文献

1
Randomized Phase II Study of Duligotuzumab (MEHD7945A) vs. Cetuximab in Squamous Cell Carcinoma of the Head and Neck (MEHGAN Study).杜利戈图单抗（MEHD7945A）与西妥昔单抗治疗头颈部鳞状细胞癌的随机II期研究（MEHGAN研究）。
Front Oncol. 2016 Oct 31;6:232. doi: 10.3389/fonc.2016.00232. eCollection 2016.
2
HER3 Targeting Sensitizes HNSCC to Cetuximab by Reducing HER3 Activity and HER2/HER3 Dimerization: Evidence from Cell Line and Patient-Derived Xenograft Models.靶向HER3通过降低HER3活性和HER2/HER3二聚化使头颈部鳞状细胞癌对西妥昔单抗敏感：来自细胞系和患者来源异种移植模型的证据
Clin Cancer Res. 2017 Feb 1;23(3):677-686. doi: 10.1158/1078-0432.CCR-16-0558. Epub 2016 Jun 29.
3
Heregulin and HER3 are prognostic biomarkers in oropharyngeal squamous cell carcinoma.Heregulin和HER3是口咽鳞状细胞癌的预后生物标志物。
Cancer. 2015 Oct 15;121(20):3600-11. doi: 10.1002/cncr.29549. Epub 2015 Jul 20.
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Afatinib versus methotrexate as second-line treatment in patients with recurrent or metastatic squamous-cell carcinoma of the head and neck progressing on or after platinum-based therapy (LUX-Head & Neck 1): an open-label, randomised phase 3 trial.阿法替尼对比甲氨蝶呤用于铂类治疗后进展的复发性或转移性头颈部鳞状细胞癌患者的二线治疗（LUX-Head & Neck 1）：一项开放标签、随机、III 期研究。
Lancet Oncol. 2015 May;16(5):583-94. doi: 10.1016/S1470-2045(15)70124-5. Epub 2015 Apr 16.
5
Combination of anti-HER3 antibody MM-121/SAR256212 and cetuximab inhibits tumor growth in preclinical models of head and neck squamous cell carcinoma.抗HER3抗体MM-121/SAR256212与西妥昔单抗联合使用可抑制头颈部鳞状细胞癌临床前模型中的肿瘤生长。
Mol Cancer Ther. 2014 Jul;13(7):1826-36. doi: 10.1158/1535-7163.MCT-13-1093. Epub 2014 Apr 18.
6
Mechanisms of acquired resistance to cetuximab: role of HER (ErbB) family members.西妥昔单抗获得性耐药机制：HER（ErbB）家族成员的作用
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