Beijing National Laboratory of Molecular Sciences (BNLMS), Key Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of Education, College of Chemistry, Peking University, Beijing 100871, China.
Chem Soc Rev. 2017 Apr 18;46(8):2306-2362. doi: 10.1039/c6cs00737f.
N-Tosylhydrazones have recently emerged as useful synthons in a variety of transition-metal-catalyzed and transition-metal-free reactions, which affords novel methodologies for the formation of carbon-carbon and carbon-heteroatom bonds. In this context, it has been found that N-tosylhydrazones can be used as versatile building blocks in the construction of a range of cyclic compounds. In this review, cyclization reactions based on N-tosylhydrazones as substrates are discussed. A series of cyclic compounds, including aromatic and non-aromatic ring systems, are demonstrated to be easily constructed by cyclizations with N-tosylhydrazones.
N-对甲苯磺酰腙最近作为各种过渡金属催化和无过渡金属反应中的有用的合成子出现，为碳-碳和碳-杂原子键的形成提供了新的方法。在这种情况下，已经发现 N-对甲苯磺酰腙可用作构建一系列环状化合物的多功能构建块。在这篇综述中，讨论了以 N-对甲苯磺酰腙作为底物的环化反应。一系列的环状化合物，包括芳香族和非芳香族的环系，通过 N-对甲苯磺酰腙的环化反应很容易构建。
