Benova D, Kiradzhiev G, Nikolova M A
Institute of Roentgenology and Radiobiology, Sofia, Bulgaria.
Acta Physiol Pharmacol Bulg. 1987;13(4):60-5.
Hypothermic response to a range of doses of WR-2721 (S-2-/3 aminopropylamino/-ethylthiophosphate) was studied in the rat. Time of hypothermia appearance, time and extent of maximum hypothermia, and pattern of body temperature recovery were all observed to depend upon the level of drug dose administered. The role of such hypothermia in systemic toxicity of the drug is discussed. The authors believe it to result from insufficiency of thermoregulation in small mammals, and to be of no practical importance for clinical application of the drug.
在大鼠中研究了对一系列剂量的WR-2721（S-2-/3-氨丙基氨基/-乙基硫代磷酸酯）的低温反应。观察到低温出现的时间、最大低温的时间和程度以及体温恢复模式均取决于给药的药物剂量水平。讨论了这种低温在药物全身毒性中的作用。作者认为这是由于小型哺乳动物体温调节不足所致，对该药物的临床应用没有实际重要性。
