Wagner M, Sedlmeier H, Wustrow T, Messerschmidt O
Strahlentherapie. 1980 Jul;156(7):486-91.
The toxicity of the chemical radioprotection substance WR 2721 (S-2-(3-aminopropylamino)ethyl-thiophosphate) was examined in 25 beagles. The study showed that the toxicity of the substance increases as the dose gets higher. Between the doses 200 and 250 mg/kg of body weight, the increase of toxicity was significantly greater than could be expected on the basis of the dose difference. Until a dose of 200 mg/kg, the authors found no side effects which would have disturbed vital functions, but higher doses led to marked symptoms of intoxication.
在25只比格犬身上检测了化学辐射防护物质WR 2721（S-2-(3-氨丙基氨基)乙基硫代磷酸盐）的毒性。研究表明，该物质的毒性随着剂量的增加而增加。在体重200至250毫克/千克的剂量之间，毒性的增加明显大于基于剂量差异所预期的增加。在剂量达到200毫克/千克之前，作者未发现会干扰生命功能的副作用，但更高的剂量会导致明显的中毒症状。
