日本组织学分类和牛津分类系统中的T评分可预测日本IgA肾病患者的肾脏预后。
The Japanese Histologic Classification and T-score in the Oxford Classification system could predict renal outcome in Japanese IgA nephropathy patients.
作者信息
Kaihan Ahmad Baseer, Yasuda Yoshinari, Katsuno Takayuki, Kato Sawako, Imaizumi Takahiro, Ozeki Takaya, Hishida Manabu, Nagata Takanobu, Ando Masahiko, Tsuboi Naotake, Maruyama Shoichi
机构信息
Department of Nephrology/CKD initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan.
出版信息
Clin Exp Nephrol. 2017 Dec;21(6):986-994. doi: 10.1007/s10157-017-1393-x. Epub 2017 Mar 27.
BACKGROUND
The Oxford Classification is utilized globally, but has not been fully validated. In this study, we conducted a comparative analysis between the Oxford Classification and Japanese Histologic Classification (JHC) to predict renal outcome in Japanese patients with IgA nephropathy (IgAN).
METHODS
A retrospective cohort study including 86 adult IgAN patients was conducted. The Oxford Classification and the JHC were evaluated by 7 independent specialists. The JHC, MEST score in the Oxford Classification, and crescents were analyzed in association with renal outcome, defined as a 50% increase in serum creatinine.
RESULTS
In multivariate analysis without the JHC, only the T score was significantly associated with renal outcome. While, a significant association was revealed only in the JHC on multivariate analysis with JHC.
CONCLUSIONS
The JHC and T score in the Oxford Classification were associated with renal outcome among Japanese patients with IgAN. Superiority of the JHC as a predictive index should be validated with larger study population and cohort studies in different ethnicities.
背景
牛津分类在全球范围内被广泛使用，但尚未得到充分验证。在本研究中，我们对牛津分类和日本组织学分类（JHC）进行了比较分析，以预测日本IgA肾病（IgAN）患者的肾脏预后。
方法
进行了一项回顾性队列研究，纳入86例成年IgAN患者。由7名独立专家对牛津分类和JHC进行评估。分析JHC、牛津分类中的MEST评分以及新月体与肾脏预后的相关性，肾脏预后定义为血清肌酐升高50%。
结果
在不纳入JHC的多变量分析中，仅T评分与肾脏预后显著相关。而在纳入JHC的多变量分析中，仅JHC显示出显著相关性。
结论
在日本IgAN患者中，JHC和牛津分类中的T评分与肾脏预后相关。JHC作为预测指标的优越性应在更大规模的研究人群和不同种族的队列研究中进行验证。
Zotero 插件