Nasri Hamid, Mortazavi Mojgan, Ghorbani Ali, Shahbazian Heshmatollah, Kheiri Soleiman, Baradaran Azar, Emami-Naieni Afsoon, Saffari Maryam, Mardani Saeed, Momeni Ali, Madihi Yahya, Baradaran-Ghahfarokhi Milad, Rafieian-Kopaie Mahmoud, Hedayati Parin, Baradaran Shahzad, Ardalan Mohammadreza, Sajjadieh Shahram, Assarzadegan Naziheh, Ahmadi Soleimani Seyed Mohammad, Tamadon Mohamad Reza
Department of Nephrology, Division of Nephropathology, Isfahan University of Medical Sciences, Isfahan,Iran.
Isfahan Kidney Disease Research Center, Isfahan University of Medical Sciences, Isfahan , Iran.
J Nephropathol. 2012 Apr;1(1):31-42. doi: 10.5812/jnp.7. Epub 2012 Apr 5.
There is a limited knowledge about the morphological features of IgA nephropathy (IgAN)in the middle east region.
The objective of this study was to evaluate the spectrum of histopathological findings in IgAN patients at our laboratory.
At this work, an observational study reported which was conducted on IgAN patients using the Oxford-MEST classification system.
In this survey, of 102 patients 71.6 % were male. The mean age of the patients was 37.7 ± 13.6 years. Morphologic variables of MEST classification was as follows; M1: 90.2 %, E: 32 %, S: 67 % also,T in grads I and II were in 30% and 19% respectively, while 51% were in grade zero. A significant difference was observed in segmental glomerulosclerosis (P=0.003) and interstitial fibrosis/tubular atrophy frequency distribution (P= 0.045), between males and females . Furthermore, it was found that mesangial hypercellularity was more prevalent in yonger patients. Moreover, there was a significant correlation between serum creatinine and crescents (P<0.001). There was also significant correlation of serum creatinine with segmental glomerulosclerosis (P<0.001).
Higher prevalence of segmental glomerulosclerosis and interstitial fibrosis/ tubular atrophy, as the two of, four variables of Oxford-MEST classification of IgAN in male patients further attests that male gender is a risk factor in this disease.In this study the significant correlation between serum creatinine and crescent was in an agreement with previous studies and suggests for the probable accomodation of extracapillary proliferation as a new variable in MEST system.
中东地区对IgA肾病（IgAN）形态学特征的了解有限。
本研究的目的是评估我们实验室中IgAN患者的组织病理学检查结果范围。
在这项工作中，报告了一项对IgAN患者进行的观察性研究，该研究使用牛津-MEST分类系统。
在本次调查中，102例患者中71.6%为男性。患者的平均年龄为37.7±13.6岁。MEST分类的形态学变量如下：M1：90.2%，E：32%，S：67%，T在I级和II级中的比例分别为30%和19%，而51%为0级。男性和女性在节段性肾小球硬化（P=0.003）和间质纤维化/肾小管萎缩频率分布（P=0.045）方面存在显著差异。此外，发现系膜细胞增多在年轻患者中更为普遍。此外，血清肌酐与新月体之间存在显著相关性（P<0.001）。血清肌酐与节段性肾小球硬化也存在显著相关性（P<0.001）。
节段性肾小球硬化和间质纤维化/肾小管萎缩的较高患病率，作为IgAN牛津-MEST分类四个变量中的两个，在男性患者中进一步证明男性性别是该疾病的一个危险因素。在本研究中，血清肌酐与新月体之间的显著相关性与先前的研究一致，并表明可能将毛细血管外增生作为MEST系统中的一个新变量。
