Arosio Paolo, Elia Leonardo, Poli Maura
Laboratory of Molecular Biology, Department of Molecular and Translational Medicine, University of Brescia, Brescia, Italy.
Humanitas Clinical and Research Center, Rozzano, MI, Italy.
IUBMB Life. 2017 Jun;69(6):414-422. doi: 10.1002/iub.1621. Epub 2017 Mar 27.
Ferritin is considered the major iron storage protein which maintains a large iron core in its cavity and has ferroxidase activity. There are many types of ferritin particularly in prokaryotes that include the canonical 24-mer FTN molecules, the heme-containing BFR, the smaller 12-mer DPS and the newly recognized EncFtn of encapsulin that forms a very large iron storage compartment. Recent studies show that ferritin function is more dynamic than previous depicted and new mechanisms of ferritin iron recycling are emerging. They participate to the regulation of cellular iron homeostasis as those of ferritin biosynthesis, cooperating also with the iron-dependent mechanism of cellular iron secretion. Some of these basic processes are in common between unicellular and animal cells, and this review aims at discussing the findings on the connections between iron storage, cellular iron regulation and ferritin iron recycling that have been explored in unicellular organisms and in animals. © 2017 IUBMB Life, 69(6):414-422, 2017.
铁蛋白被认为是主要的铁储存蛋白，其在腔内维持一个大的铁核心并具有铁氧化酶活性。铁蛋白有多种类型，特别是在原核生物中，包括典型的24聚体FTN分子、含血红素的BFR、较小的12聚体DPS以及新发现的形成非常大的铁储存隔室的封装菌素的EncFtn。最近的研究表明，铁蛋白的功能比以前描述的更具动态性，铁蛋白铁循环的新机制正在出现。它们参与细胞铁稳态的调节，如同铁蛋白生物合成一样，也与细胞铁分泌的铁依赖性机制协同作用。这些基本过程在单细胞和动物细胞之间有一些共同之处，本综述旨在讨论在单细胞生物和动物中探索的关于铁储存、细胞铁调节和铁蛋白铁循环之间联系的研究结果。© 2017国际生物化学与分子生物学联盟生命科学，69(6):414 - 422，2017。
