Choi David, Bilsky Mark, Fehlings Michael, Fisher Charles, Gokaslan Ziya
Department of Neurosurgery, the Natio-nal Hospital for Neurology and Neuros-urgery, London, UK.
Department of Neurosurgery, Memorial Sloan-Kettering Cancer Center, New York.
Neurosurgery. 2017 Mar 1;80(3S):S131-S137. doi: 10.1093/neuros/nyw084.
Surgery for spinal metastases remains the mainstay treatment for pain, instability, and neurological deterioration due to tumor infiltration of the spine. However, several new therapies are emerging which may improve outcomes further, and in some cases even replace the need for surgery. We now have a better understanding of which factors influence survival and quality of life after surgery, and this underpins the development and application of new treatments, and assessment of outcome.Depending on genetic subtyping of tumors, novel immunotherapies and chemotherapies may be very effective in prolonging quality of life. New surgical techniques allow smaller, quicker, and safer operations with less blood loss, pain, and quicker recovery after surgery. Radiation treatments have also leapt forward with the greater accuracy and higher doses possible from intensity-modulated photon radiation, stereotactic body radiation treatment, proton beam therapy, or carbon ion treatment. Combined with more advanced materials for vertebral body stabilization, computer navigation systems, and robotics, more can be done at earlier or later stages of the spinal disease than was previously possible, resulting in more options and improved outcomes for patients.
脊柱转移瘤的手术仍然是治疗因肿瘤浸润脊柱而导致的疼痛、不稳定和神经功能恶化的主要方法。然而,一些新的治疗方法正在出现,这些方法可能会进一步改善治疗效果,在某些情况下甚至可以取代手术的必要性。我们现在对哪些因素会影响手术后的生存率和生活质量有了更好的理解,这为新治疗方法的开发和应用以及治疗效果的评估奠定了基础。根据肿瘤的基因亚型,新型免疫疗法和化疗可能在延长生活质量方面非常有效。新的手术技术使手术切口更小、速度更快、更安全,术中失血更少、疼痛更轻,术后恢复更快。放射治疗也取得了飞跃式发展,强度调制光子放疗、立体定向体部放疗、质子束治疗或碳离子治疗能够实现更高的精度和更高的剂量。结合用于椎体稳定的更先进材料、计算机导航系统和机器人技术,在脊柱疾病的早期或晚期阶段可以完成比以前更多的治疗,从而为患者带来更多选择并改善治疗效果。