微小RNA对心血管强健性具有重要影响。
MicroRNAs Make a Difference in Cardiovascular Robustness.
作者信息
Bakker Rachael, Carthew Richard W
机构信息
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA.
Department of Molecular Biosciences, Northwestern University, Evanston, IL 60208, USA; Department of Biochemistry and Molecular Genetics, Northwestern University, Chicago, IL 60611, USA.
出版信息
Dev Cell. 2017 Mar 27;40(6):515-516. doi: 10.1016/j.devcel.2017.03.009.
Abstract
Invertebrate microRNAs (miRNAs) can suppress developmental variability that is caused by environmental and genetic variation. In this issue of Developmental Cell, Kasper et al. (2017) show that zebrafish miRNAs suppress variability in cardiovascular development during embryogenesis, providing insight into the conserved link between miRNAs and robustness.
摘要
无脊椎动物的微小RNA（miRNA）可以抑制由环境和基因变异引起的发育变异性。在本期《发育细胞》中，卡斯珀等人（2017年）表明，斑马鱼的miRNA在胚胎发生过程中抑制心血管发育的变异性，这为深入了解miRNA与发育稳健性之间的保守联系提供了线索。
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