ICAR-Central Inland Fisheries Research Institute, Barrackpore, Kolkata 700 120, West Bengal, India.
Centre For Aquaculture Research, Extension & Livelihood, Department of Aquaculture Management & Technology, Vidyasagar University, Midnapore 721102, West Bengal, India.
Gene. 2018 Dec 30;679:202-211. doi: 10.1016/j.gene.2018.09.008. Epub 2018 Sep 7.
MicroRNAs (miRNAs) are the class of small, non-coding RNAs that are produced from precursor transcripts by subsequent processing steps mediated by members of the RNaseIII family, Dicer and Drosha protein within cell. The importance of zebrafish miRNAs in regulation of normal cellular development and support to various kinds of metabolism process. Although the zebrafish model provides a fundamental platform for the study of developmental biology but recent work with zebrafish model has expanded its appliance to a broad range of experimental studies relevant to different kind of human diseases. Presently, the zebrafish model is used for the study of cardiovascular disease, schizophrenia, bipolar I disorder in eyes, psoriasis, spinal cord injury, cancer and diabetes that showing in some selected miRNAs are regulate these diseases in molecular levels. Here, a superior drive performed to depict the fundamental utilization of the zebrafish miRNAs that targeted to several clinical diseases connected to human. This review aims to provide a summary of understanding of the cellular mechanism which is responsible for selected diseases and suggests some therapeutic application for inhibition of miRNA functions.
微小 RNA（miRNA）是一类小的非编码 RNA，它们由前体转录本通过细胞内 RNaseIII 家族成员 Dicer 和 Drosha 蛋白的后续加工步骤产生。斑马鱼 miRNA 在调节正常细胞发育和支持各种代谢过程中的重要性。尽管斑马鱼模型为发育生物学的研究提供了一个基本的平台，但最近对斑马鱼模型的研究已经将其应用扩展到与各种人类疾病相关的广泛的实验研究中。目前，斑马鱼模型被用于研究心血管疾病、精神分裂症、双相 I 型障碍、银屑病、脊髓损伤、癌症和糖尿病，这些疾病的某些选定 miRNA 调节这些疾病在分子水平上。在这里，进行了一项卓越的研究，以描述针对与人类相关的几种临床疾病的斑马鱼 miRNA 的基本用途。本综述旨在提供对负责选定疾病的细胞机制的理解，并提出抑制 miRNA 功能的一些治疗应用。
