神经内分泌分化是低分化结直肠癌的一个预后因素吗？
Is neuroendocrine differentiation a prognostic factor in poorly differentiated colorectal cancer?
作者信息
Chen Yue, Liu Fang, Meng Qingkai, Ma Siping
机构信息
Department of colorectal surgery, Cancer Hospital of China Medical University, Liaoning Cancer Hospital & Institute, No. 44 Xiaoheyan Road, Dadong District, Shenyang, 110042, Liaoning Province, People's Republic of China.
出版信息
World J Surg Oncol. 2017 Mar 28;15(1):71. doi: 10.1186/s12957-017-1139-y.
BACKGROUND
To determine the prognostic relevance of neuroendocrine differentiation in poorly differentiated colorectal cancer.
METHODS
The clinicopathological features and survival of 70 patients with poorly differentiated colorectal cancer were analyzed retrospectively. Chromogranin A and synaptophysin were used as neuroendocrine markers. Patients were followed-up for more than 3 years or until death.
RESULTS
Of these 70 patients, 36 showed neuroendocrine differentiation. In univariate prognostic analysis, the patients with lymph node metastasis (P < 0.001), advanced TNM stage (P < 0.001), and neuroendocrine differentiation (P = 0.003) tended to have a poor prognosis. However, only lymph node metastasis was associated with a poor prognosis in multivariate analysis (P < 0.001). Patients with neuroendocrine differentiation were associated with lymph node metastasis (P = 0.006).
CONCLUSIONS
Neuroendocrine differentiation in poorly differentiated colorectal cancer was not a direct prognostic factor in these patients. Lymph node metastasis was a direct prognostic factor in these patients. Patients with neuroendocrine differentiation were associated with lymph node metastasis.
背景
确定神经内分泌分化在低分化结直肠癌中的预后相关性。
方法
回顾性分析70例低分化结直肠癌患者的临床病理特征及生存情况。采用嗜铬粒蛋白A和突触素作为神经内分泌标志物。对患者进行了超过3年的随访或直至死亡。
结果
在这70例患者中，36例显示神经内分泌分化。在单因素预后分析中，有淋巴结转移（P＜0.001）、TNM分期较晚（P＜0.001）以及神经内分泌分化（P = 0.003）的患者预后往往较差。然而，在多因素分析中，只有淋巴结转移与预后不良相关（P＜0.001）。神经内分泌分化的患者与淋巴结转移相关（P = 0.006）。
结论
低分化结直肠癌中的神经内分泌分化并非这些患者的直接预后因素。淋巴结转移是这些患者的直接预后因素。神经内分泌分化的患者与淋巴结转移相关。
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