Xu Fangying, Liu Qin, Han Fengyan, Xu Enping, Lai Maode, Zhao Zhongsheng
Key Laboratory of Disease Proteomics of Zhejiang Province, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China.
Department of Pathology, Zhejiang Provincial People's Hospital, Hangzhou 310014, China.
Zhejiang Da Xue Xue Bao Yi Xue Ban. 2016 Jan;45(1):24-30. doi: 10.3785/j.issn.1008-9292.2016.01.04.
To investigate the association of neuroendocrine differentiation with progression and prognosis of gastric adenocarcinoma.
Clinicopathological data of 240 patients with gastric adenocarcinomas were retrospectively analyzed. The expression of chromogranin A, synaptophysin and secrectagogin in cancer tissue was assessed by immunohistochemistry. The association of neuoroendocrine differentiation parameters with disease progression and survival of patients was analyzed.
The expression of synaptophysin was positively correlated with depth of invasion and secretagogin more often expressed in cases with lymph node metastasis. In Lauren diffuse type of cancer, expression of chromogranin A and secretagogin was unfavorable prognostic predictor. In TNM stage II adenocarcinoma, expression of chromogranin A and synaptophysin related to poor survival, and multivariate Cox proportional hazard model showed that synaptophysin was an independent predictor for poor survival.
Neuroendocrine differentiation predicts deeper depth of invasion, more possibility of lymph node metastasis and poor survival in gastric adenocarcinoma.
探讨神经内分泌分化与胃腺癌进展及预后的相关性。
回顾性分析240例胃腺癌患者的临床病理资料。采用免疫组织化学法评估癌组织中嗜铬粒蛋白A、突触素和分泌粒蛋白的表达。分析神经内分泌分化参数与患者疾病进展和生存的相关性。
突触素的表达与浸润深度呈正相关，分泌粒蛋白在淋巴结转移病例中更常表达。在劳伦弥漫型癌中，嗜铬粒蛋白A和分泌粒蛋白的表达是不良预后指标。在TNM II期腺癌中，嗜铬粒蛋白A和突触素的表达与生存不良相关，多因素Cox比例风险模型显示突触素是生存不良的独立预测指标。
神经内分泌分化预示胃腺癌浸润深度更深、淋巴结转移可能性更大及生存不良。
