Basolo F, Fontanini G, Squartini F
Institute of Pathological Anatomy and Histology, University of Pisa, Italy.
Cancer Res. 1988 Jun 1;48(11):3197-202.
In BALB/cfC3H and BALB/cfRIII virgin female mice, i.e., BALB/c mice carrying milk-transmitted C3H and those carrying RIII murine mammary tumor virus infection, respectively, mammary noduligenesis and tumorigenesis are remarkably different. Focal hyperplastic alveolar changes or hyperplastic alveolar nodules were removed from BALB/cfRIII or BALB/cfC3H breeding female donors and transplanted into the gland-free mammary fat pads of syngeneic BALB/c virgin female recipients with or without hormonal supplementation. The results obtained have shown significant differences in: (a) the morphological type of outgrowths; (b) the incidence of malignant transformations; and (c) the hormonal responsiveness of the tumors arisen after pituitary transplants.
在BALB/cfC3H和BALB/cfRIII处女雌性小鼠中，即分别携带经乳汁传播的C3H病毒的BALB/c小鼠和携带RIII鼠乳腺肿瘤病毒感染的BALB/c小鼠，乳腺结节形成和肿瘤发生有显著差异。从BALB/cfRIII或BALB/cfC3H繁殖雌性供体中取出局灶性增生性肺泡改变或增生性肺泡结节，并移植到同基因BALB/c处女雌性受体的无腺体乳腺脂肪垫中，有无激素补充均可。所得结果显示在以下方面存在显著差异：(a) 生长物的形态类型；(b) 恶性转化的发生率；(c) 垂体移植后出现的肿瘤的激素反应性。
