PIFA-BF·OEt介导的烯酰胺分子内区域选择性多米诺环化反应：一种合成四氢异喹啉-恶唑-2(3H)-酮的新方法。
PIFA-BF·OEt mediated intramolecular regioselective domino cyclization of ynamides: A novel method for the synthesis of tetrahydroisoquinoline-oxazol-2(3H)-ones.
作者信息
Ieawsuwan Winai, Ruchirawat Somsak
机构信息
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
Laboratory of Medicinal Chemistry, Chulabhorn Research Institute, 54 Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; Chemical Biology Program, Chulabhorn Graduate Institute, 54 Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand; Center of Excellence on Environmental Health and Toxicology (EHT), Ministry of Education, 54 Kamphaeng Phet 6 Road, Laksi, Bangkok 10210, Thailand.
出版信息
Bioorg Med Chem. 2017 Jun 1;25(11):2856-2867. doi: 10.1016/j.bmc.2017.03.034. Epub 2017 Mar 19.
The transition metal-free intramolecular regioselective domino cyclization of N-Boc protected ynamides has been developed to provide the corresponding tetrahydroisoquinoline-oxazo-2(3H)-ones in moderate to good yields.
已开发出无过渡金属的N - Boc保护的烯酰胺分子内区域选择性多米诺环化反应，以中等至良好的产率提供相应的四氢异喹啉-恶唑-2(3H)-酮。
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