Imtiaz Salman, Salman Beena, Nasir Kiran, Drohlia Murtaza F, Ahmad Aasim
Department of Nephrology, Dorab Patel Post Graduate Training and Research Center, The Kidney Center Post Graduate Training Institute, Karachi, Pakistan.
Department of Biostatistics and Research, Dow University of Health Sciences, Karachi, Pakistan.
Saudi J Kidney Dis Transpl. 2017 Mar-Apr;28(2):307-312. doi: 10.4103/1319-2442.202794.
Patients with diabetes may have kidney diseases other than the diabetic kidney disease. Kidney biopsy is the investigation of choice when this is suspected. This retrospective analysis included all patients known to have diabetes mellitus (DM) and who had a kidney biopsy at our center between 1998 and 2014. The aim of this study was to assess if an association exists between the clinical factors on the presence or absence of diabetic nephropathy (DNP). A total number of 206 patients were included in our study. The association between the diabetic retinopathy (DRP) and DNP was high (P = 0.001). We found that the DRP is highly specific for the presence of DNP [89.7% (78 out of 87)] whereas sensitivity of DRP for DNP was 56.3% (67 out of 119). Among other factors, only duration of DM showed a significant association (P = 0.005) (odds ratio: 1.1085 and confidence interval: 1.025-1.149) with the development of DNP. We conclude that the absence of DRP is strongly associated with the presence of nondiabetic renal disease while the presence of DRP has a low sensitivity for the presence of DNP.
糖尿病患者可能患有除糖尿病肾病之外的肾脏疾病。当怀疑有这种情况时，肾活检是首选的检查方法。这项回顾性分析纳入了所有已知患有糖尿病（DM）且于1998年至2014年期间在本中心接受肾活检的患者。本研究的目的是评估临床因素与糖尿病肾病（DNP）的存在与否之间是否存在关联。我们的研究共纳入了206例患者。糖尿病视网膜病变（DRP）与DNP之间的关联度很高（P = 0.001）。我们发现，DRP对DNP的存在具有高度特异性[89.7%（87例中的78例）]，而DRP对DNP的敏感性为56.3%（119例中的67例）。在其他因素中，只有糖尿病病程与DNP的发生显示出显著关联（P = 0.005）（比值比：1.1085，置信区间：1.025 - 1.149）。我们得出结论，DRP的缺失与非糖尿病性肾病的存在密切相关，而DRP的存在对DNP的存在敏感性较低。
