• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

脉冲振荡法在老年慢性阻塞性肺疾病患者中的临床应用价值

Clinical application value of impulse oscillometry in geriatric patients with COPD.

作者信息

Liu Zhonghui, Lin Lianjun, Liu Xinmin

机构信息

Geriatrics Department, Peking University First Hospital, Beijing, People's Republic of China.

出版信息

Int J Chron Obstruct Pulmon Dis. 2017 Mar 15;12:897-905. doi: 10.2147/COPD.S129974. eCollection 2017.

DOI:10.2147/COPD.S129974
PMID:28352170
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5358990/
Abstract

BACKGROUND

The diagnosis and assessment of COPD rely mainly on the use of spirometry, which is an effort-dependent test and requires good patient cooperation. Impulse oscillometry (IOS) is a non-volitional method that requires less effort and cooperation and presents advantages for geriatric patients. However, the clinical application value of IOS in geriatric patients with COPD remains unclear.

AIM

The aim of this study was to investigate the clinical application value of IOS in geriatric patients with COPD.

SUBJECTS AND METHODS

A total of 234 subjects were retrospectively enrolled in this study, including 133 patients with COPD and 101 healthy volunteers. All the participants underwent IOS and spirometry examination. The data were collected and analyzed in the overall group, the geriatric group (aged ≥65 years), and the advanced elderly group (aged ≥80 years).

RESULTS

  1. In COPD patients, a significant increase in respiratory impedance (Z5), resonant frequency (Fres), and respiratory resistance (R5, R20, R5-R20) and a decrease in respiratory reactance (X5) were observed in the overall group, the geriatric group, and the advanced elderly group compared with the healthy control subjects. 2) The IOS parameters correlated well with spirometry in COPD. In particular, R5-R20 showed the best correlation with forced expiratory volume in 1 second (FEV) in the different age groups. 3) Fres and R5-R20 had the best diagnostic efficiency for COPD. The area under the curve (AUC) values for Fres, expressed by the receiver operating characteristic (ROC) curve, were 0.905, 0.909, and 0.914, for the different age groups, respectively. 4) The optimal cutoff values for Fres to diagnose airflow obstruction from ROC curves was 17.715 in the COPD patients. Its sensitivity and specificity were 0.789 and 0.931, respectively, and the cutoff values were similar in geriatric and advanced elderly patients.

CONCLUSION

IOS demonstrated good relevance compared with spirometry for geriatric patients with COPD. IOS may serve as an alternative method for spirometry in elderly subjects for the evaluation of the state of COPD.

摘要

背景

慢性阻塞性肺疾病（COPD）的诊断和评估主要依赖于肺量计的使用，这是一项依赖用力的检查，需要患者良好的配合。脉冲振荡法（IOS）是一种无需用力的方法，所需的努力和配合较少，对老年患者具有优势。然而，IOS在老年COPD患者中的临床应用价值仍不明确。

目的

本研究旨在探讨IOS在老年COPD患者中的临床应用价值。

对象与方法

本研究共回顾性纳入234名受试者，包括133例COPD患者和101名健康志愿者。所有参与者均接受IOS和肺量计检查。对总体组、老年组（年龄≥65岁）和高龄老年组（年龄≥80岁）的数据进行收集和分析。

结果

1）在COPD患者中，与健康对照受试者相比，总体组、老年组和高龄老年组的呼吸阻抗（Z5）、共振频率（Fres）、呼吸阻力（R5、R20、R5-R20）显著增加，呼吸电抗（X5）降低。2）COPD患者中IOS参数与肺量计检查结果相关性良好。特别是，R5-R20在不同年龄组中与第1秒用力呼气容积（FEV）的相关性最佳。3）Fres和R5-R20对COPD的诊断效率最佳。根据受试者工作特征（ROC）曲线得出的Fres曲线下面积（AUC）值，在不同年龄组中分别为0.905、0.909和0.914。4）根据ROC曲线，COPD患者中用于诊断气流阻塞的Fres最佳截断值为17.715。其敏感性和特异性分别为0.789和0.931，老年和高龄老年患者的截断值相似。

结论

对于老年COPD患者，IOS与肺量计检查显示出良好的相关性。IOS可作为老年受试者肺量计检查的替代方法，用于评估COPD状态。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8aa/5358990/edc8717e5555/copd-12-897Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8aa/5358990/2b9ef18cdd4a/copd-12-897Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8aa/5358990/edc8717e5555/copd-12-897Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8aa/5358990/2b9ef18cdd4a/copd-12-897Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/f8aa/5358990/edc8717e5555/copd-12-897Fig2.jpg

相似文献

1
Clinical application value of impulse oscillometry in geriatric patients with COPD.脉冲振荡法在老年慢性阻塞性肺疾病患者中的临床应用价值
Int J Chron Obstruct Pulmon Dis. 2017 Mar 15;12:897-905. doi: 10.2147/COPD.S129974. eCollection 2017.
2
[The diagnostic utility of the Macao predictive values of impulse oscillometry for chronic obstructive pulmonary disease in patients over 45 years old].[脉冲振荡法澳门预测值对45岁以上慢性阻塞性肺疾病患者的诊断效用]
Zhonghua Jie He He Hu Xi Za Zhi. 2016 Jan;39(1):41-6. doi: 10.3760/cma.j.issn.1001-0939.2016.01.012.
3
Impulse oscillometry system as an alternative diagnostic method for chronic obstructive pulmonary disease.脉冲振荡法系统作为慢性阻塞性肺疾病的一种替代诊断方法。
Medicine (Baltimore). 2017 Nov;96(46):e8543. doi: 10.1097/MD.0000000000008543.
4
Application Value of Broadband 3-Dimensional Impulse Oscillometry in COPD.宽带三维脉冲震荡技术在 COPD 中的应用价值。
Int J Chron Obstruct Pulmon Dis. 2021 Feb 4;16:215-223. doi: 10.2147/COPD.S285927. eCollection 2021.
5
Diagnostic value of impulse oscillometry in chronic obstructive pulmonary disease: a multicentre, retrospective, observational study.脉冲振荡法在慢性阻塞性肺疾病中的诊断价值：一项多中心、回顾性、观察性研究。
BMJ Open. 2024 Oct 8;14(10):e087687. doi: 10.1136/bmjopen-2024-087687.
6
Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system.采用脉冲振荡系统评估慢性阻塞性肺疾病患者的呼吸阻抗
Mol Med Rep. 2014 Nov;10(5):2694-700. doi: 10.3892/mmr.2014.2528. Epub 2014 Sep 2.
7
Accuracy of forced oscillation technique to assess lung function in geriatric COPD population.强迫振荡技术评估老年慢性阻塞性肺疾病患者肺功能的准确性
Int J Chron Obstruct Pulmon Dis. 2016 May 26;11:1105-18. doi: 10.2147/COPD.S102222. eCollection 2016.
8
Significances of spirometry and impulse oscillometry for detecting small airway disorders assessed with endobronchial optical coherence tomography in COPD.肺活量测定法和脉冲振荡法在检测慢性阻塞性肺疾病中通过支气管内光学相干断层扫描评估的小气道疾病方面的意义。
Int J Chron Obstruct Pulmon Dis. 2018 Oct 1;13:3031-3044. doi: 10.2147/COPD.S172639. eCollection 2018.
9
Impulse oscillometry for detection of small airway dysfunction in subjects with chronic respiratory symptoms and preserved pulmonary function.脉冲振荡法用于检测有慢性呼吸道症状且肺功能正常的受试者的小气道功能障碍。
Respir Res. 2021 Feb 24;22(1):68. doi: 10.1186/s12931-021-01662-7.
10
Comparative evaluation of expiratory airflow limitation between patients with COPD and BE using IOS.使用 IOS 对 COPD 和 BE 患者呼气气流受限进行比较评估。
Sci Rep. 2021 Feb 25;11(1):4524. doi: 10.1038/s41598-021-84028-9.

引用本文的文献

1
Managing Small Airways Dysfunction in COPD Patients in Real Life Under Fixed Triple Combination of Beclomethasone/Formoterol/Glycopyrronium: The MASCOT Real World Evidence Study.在布地奈德/福莫特罗/格隆溴铵固定三联组合治疗下，现实生活中慢性阻塞性肺疾病患者小气道功能障碍的管理：MASCOT真实世界证据研究
Int J Chron Obstruct Pulmon Dis. 2025 May 23;20:1651-1663. doi: 10.2147/COPD.S513350. eCollection 2025.
2
Measuring lung mechanics in patients with COPD using the handheld portable rapid expiratory occlusion monitor (REOM): A cross-sectional study.使用手持式便携式快速呼气阻断监测仪（REOM）测量慢性阻塞性肺疾病（COPD）患者的肺力学：一项横断面研究。
Physiol Rep. 2025 Apr;13(7):e70307. doi: 10.14814/phy2.70307.
3

本文引用的文献

1
Change in pulmonary function in chronic obstructive pulmonary disease stage 0 patients.慢性阻塞性肺疾病0期患者的肺功能变化
Int J Clin Exp Med. 2015 Nov 15;8(11):21400-6. eCollection 2015.
2
[The diagnostic utility of the Macao predictive values of impulse oscillometry for chronic obstructive pulmonary disease in patients over 45 years old].[脉冲振荡法澳门预测值对45岁以上慢性阻塞性肺疾病患者的诊断效用]
Zhonghua Jie He He Hu Xi Za Zhi. 2016 Jan;39(1):41-6. doi: 10.3760/cma.j.issn.1001-0939.2016.01.012.
3
Advantage of impulse oscillometry over spirometry to diagnose chronic obstructive pulmonary disease and monitor pulmonary responses to bronchodilators: An observational study.
Impulse oscillometry-derived equation for prediction of abnormal FEV/FVC ratio for COPD screening in Chinese population: a multicenter cross-sectional study.
基于脉冲振荡法推导的用于预测中国人群慢性阻塞性肺疾病筛查中异常FEV/FVC比值的方程：一项多中心横断面研究
Lancet Reg Health West Pac. 2025 Feb 26;56:101501. doi: 10.1016/j.lanwpc.2025.101501. eCollection 2025 Mar.
4
Diagnosis and evaluation of small airway disease and COPD using impulse oscillometry.使用脉冲震荡技术诊断和评估小气道疾病和 COPD。
Sci Rep. 2024 Nov 14;14(1):28030. doi: 10.1038/s41598-024-79818-w.
5
Impulse oscillometry system and pulmonary function test assessment of the impact of tumor location, staging, and pathological type on lung function in primary lung cancer.脉冲振荡系统和肺功能测试评估原发性肺癌中肿瘤位置、分期和病理类型对肺功能的影响。
BMC Pulm Med. 2024 Nov 11;24(1):563. doi: 10.1186/s12890-024-03363-5.
6
Diagnostic value of impulse oscillometry in chronic obstructive pulmonary disease: a multicentre, retrospective, observational study.脉冲振荡法在慢性阻塞性肺疾病中的诊断价值：一项多中心、回顾性、观察性研究。
BMJ Open. 2024 Oct 8;14(10):e087687. doi: 10.1136/bmjopen-2024-087687.
7
Using Machine Learning with Impulse Oscillometry Data to Develop a Predictive Model for Chronic Obstructive Pulmonary Disease and Asthma.使用机器学习结合脉冲振荡法数据来开发慢性阻塞性肺疾病和哮喘的预测模型。
J Pers Med. 2024 Apr 9;14(4):398. doi: 10.3390/jpm14040398.
8
Impulse oscillometry indices in relation to respiratory symptoms and spirometry in the Swedish Cardiopulmonary Bioimage Study.瑞典心肺生物影像研究中与呼吸症状及肺功能测定相关的脉冲振荡法指标
ERJ Open Res. 2023 Sep 25;9(5). doi: 10.1183/23120541.00736-2022. eCollection 2023 Sep.
9
Spirometry parameters versus forced oscillometry parameters in obstructive airway disease - Is there a correlation?阻塞性气道疾病中肺量计参数与强迫振荡法参数的比较——是否存在相关性？
Lung India. 2023 May-Jun;40(3):291-294. doi: 10.4103/lungindia.lungindia_314_22.
10
Reply to: Interpreting lung oscillometry results: Z-scores instead of fixed cut-off values?回复：解读肺部振荡法结果：使用Z分数而非固定临界值？
ERJ Open Res. 2023 Mar 27;9(2). doi: 10.1183/23120541.00718-2022. eCollection 2023 Mar.
脉冲振荡法相较于肺量计在诊断慢性阻塞性肺疾病及监测肺部对支气管扩张剂反应方面的优势：一项观察性研究。
SAGE Open Med. 2015 Apr 6;3:2050312115578957. doi: 10.1177/2050312115578957. eCollection 2015.
4
Techniques of assessing small airways dysfunction.评估小气道功能障碍的技术。
Eur Clin Respir J. 2014 Oct 17;1. doi: 10.3402/ecrj.v1.25898. eCollection 2014.
5
Small airway dysfunction and flow and volume bronchodilator responsiveness in patients with chronic obstructive pulmonary disease.慢性阻塞性肺疾病患者的小气道功能障碍及气流和容积支气管扩张剂反应性
Int J Chron Obstruct Pulmon Dis. 2015 Jun 19;10:1191-7. doi: 10.2147/COPD.S82509. eCollection 2015.
6
Application of impulse oscillometry and bronchial dilation test for analysis in patients with asthma and chronic obstructive pulmonary disease.脉冲振荡法和支气管舒张试验在哮喘和慢性阻塞性肺疾病患者分析中的应用。
Int J Clin Exp Med. 2015 Jan 15;8(1):1271-5. eCollection 2015.
7
The burden of disease in older people and implications for health policy and practice.老年人的疾病负担及其对卫生政策和实践的影响。
Lancet. 2015 Feb 7;385(9967):549-62. doi: 10.1016/S0140-6736(14)61347-7. Epub 2014 Nov 6.
8
Impulse oscillometry in the diagnosis of airway resistance in chronic obstructive pulmonary disease.脉冲振荡法在慢性阻塞性肺疾病气道阻力诊断中的应用。
Adv Exp Med Biol. 2015;838:47-52. doi: 10.1007/5584_2014_49.
9
Comparison of impulse osillometry system and spirometry for diagnosis of obstructive lung disorders.脉冲振荡法系统与肺量计在阻塞性肺疾病诊断中的比较
Tanaffos. 2011;10(1):19-25.
10
Evaluation of respiratory impedance in patients with chronic obstructive pulmonary disease by an impulse oscillation system.采用脉冲振荡系统评估慢性阻塞性肺疾病患者的呼吸阻抗
Mol Med Rep. 2014 Nov;10(5):2694-700. doi: 10.3892/mmr.2014.2528. Epub 2014 Sep 2.