克什米尔人群高血压患者中的ACE I/D多态性
ACE I/D Polymorphism in Hypertensive Patients of Kashmiri Population.
作者信息
Sameer A Syed, Syeed Nidda, Tak Shahid A, Bashir Samina, Nissar Saniya, Siddiqi Mushtaq A
机构信息
Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India; Departments of Clinical Biochemistry, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, India.
Departments of Immunology and Molecular Medicine, Sher-I-Kashmir Institute of Medical Sciences, Soura, Srinagar, Kashmir, 190011, India.
出版信息
Cardiol Res. 2010 Dec;1(1):1-7. doi: 10.4021/cr101e. Epub 2010 Nov 20.
BACKGROUND
The angiotensin-converting enzyme (ACE) gene in humans has an insertion-deletion (I/D) polymorphic state in intron 16 on chromosome 17q23. This polymorphism has been widely investigated in different diseases. In this study we aimed to investigate the ACE I/D genotype frequency in hypertensive cases in Kashmiri population.
MATERIALS AND METHODS
We designed a case control study, where 52 hypertensive cases were studied for ACE I/D polymorphism against 150 age/sex matched controls taken from general population. The polymorphisms of ACE gene were investigated using polymerase chain reaction for detection of ACE I/D genotype. Fisher's Chi square test was used for calculation of P value and OR.
RESULTS
We found the frequency of ACE DD genotype to be 46.15% (24/52), II 23.07% (12/52) and DI 30.77% (16/52) in 52 hypertensive cases.
CONCLUSIONS
The ACE I/D genotype is positively associated with hypertension in our population.
背景
人类血管紧张素转换酶（ACE）基因在17号染色体q23区域的第16内含子存在插入/缺失（I/D）多态性状态。这种多态性已在不同疾病中得到广泛研究。在本研究中，我们旨在调查克什米尔人群高血压患者中ACE I/D基因型频率。
材料与方法
我们设计了一项病例对照研究，对52例高血压患者进行ACE I/D多态性研究，并与从普通人群中选取的150名年龄/性别匹配的对照进行比较。采用聚合酶链反应检测ACE基因多态性以确定ACE I/D基因型。使用Fisher卡方检验计算P值和比值比（OR）。
结果
我们发现52例高血压患者中ACE DD基因型频率为46.15%（24/52），II为23.07%（12/52），DI为30.77%（16/52）。
结论
在我们的人群中，ACE I/D基因型与高血压呈正相关。
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