Wagdi Philipp
Interventional Cardiology, HerzZentrum Hirslanden, Witellikerstr. 36, 8008 Zurich, Switzerland.
Cardiol Res. 2011 Dec;2(6):288-292. doi: 10.4021/cr109w. Epub 2011 Nov 20.
Erosion of a cardiac structure after device closure of an interatrial septal communication (IASC-C), although rare, is a major and severe adverse event which may be underreported. On the other hand, unexplained episodes of transient chest pain occur more often and may be quite distressing. We sought to define the parameters relating the devices to the adjacent cardiac structures and to determine whether computer tomography (CT) could predict erosion of atrial or aortic wall or precordial pain symptoms occurring in the first months after device implantation.
Retrospective observational study of 20 patients who underwent CT for de novo chest pain occurring after IASC-C or as a diagnostic test for suspected or proven coronary artery disease (CAD). Clinical follow up was for 20.5 ± 17.6 (6-84) months. CT was done 18 ± 10 (2-28) weeks after IASC-C.
Indentation of the aortic root was found in 11 (55%) patients, the left atrial wall in 13 (65%) and the right atrial wall in eight (40%) of patients. Contact without indentation was found in nine (45%), 6 (30%) and 11 (55%) of patients respectively.
Device indenting of the left and right atrial, as well as the aortic wall, occured in the majority of the patients examined after IASC-C. This finding may explain bouts of chest pain after the intervention in some patients, but does not predict clinically relevant erosion of a cardiac structure.
房间隔交通口封堵术后心脏结构侵蚀(IASC-C)虽罕见,但却是严重的主要不良事件,可能存在报告不足的情况。另一方面,不明原因的短暂胸痛发作更为常见,且可能相当令人苦恼。我们试图确定与封堵装置及相邻心脏结构相关的参数,并确定计算机断层扫描(CT)能否预测封堵装置植入后头几个月出现的心房或主动脉壁侵蚀或心前区疼痛症状。
对20例因IASC-C术后新发胸痛或作为疑似或确诊冠状动脉疾病(CAD)诊断检查而接受CT检查的患者进行回顾性观察研究。临床随访时间为20.5±17.6(6 - 84)个月。CT检查在IASC-C术后18±10(2 - 28)周进行。
11例(55%)患者发现主动脉根部受压,13例(65%)患者发现左心房壁受压,8例(40%)患者发现右心房壁受压。分别有9例(45%)、6例(30%)和11例(55%)患者存在无受压的接触情况。
在IASC-C术后接受检查的大多数患者中,封堵装置对左、右心房以及主动脉壁均有压迫。这一发现可能解释了部分患者术后的胸痛发作,但无法预测临床上相关的心脏结构侵蚀。