血清胆红素浓度与心房颤动之间的关系
The Relationship Between Serum Bilirubin Concentration and Atrial Fibrillation.
作者信息
Demir Mehmet, Demir Canan, Uyan Umut, Melek Mehmet
机构信息
Cardiology Department, Bursa Yuksek Ihtisas Education and Research Hospital, Bursa, Turkey.
Infectious Disease Department, Bursa Sevket Yilmaz Education and Research Hospital, Bursa, Turkey.
出版信息
Cardiol Res. 2013 Dec;4(6):186-191. doi: 10.4021/cr299w. Epub 2014 Jan 2.
BACKGROUND
Several studies have demonstrated that higher serum bilirubin inhibits the inflammation and proliferation of vascular smooth muscle cells; also there is a relationship between serum bilirubin and cardiovascular disease. However, the relationship between bilirubin and atrial fibrillation (AF) is still unknown. In our study, we compared serum bilirubin, between nonvalvular AF patients and controls.
MATERIALS AND METHOD
One hundred and two patients with nonvalvular chronic AF without any other cardiovascular disease (mean age 62.51 ± 5.88) were included in our study. One hundred age-matched healthy people with sinus rhythm were accepted as control groups (mean age 61.35 ± 5.44). Routine biochemical parameters and serum bilirubin levels were performed.
RESULTS
No statistically significant difference was found between two groups in terms of basic characteristics. Total, direct and indirect serum bilirubin levels were significantly lower among persons with AF compared to controls (0.82 ± 0.8 vs. 0.48 ± 0.5, 0.30 ± 0.2 vs. 0.19 ± 0.1 and 0.52 ± 0.5 vs. 0.29 ± 0.3 mg/dL; all P < 0.001, respectively).
CONCLUSION
As a result, our study revealed a relationship between serum bilirubin and nonvalvular AF.
背景
多项研究表明，较高的血清胆红素可抑制血管平滑肌细胞的炎症和增殖；血清胆红素与心血管疾病之间也存在关联。然而，胆红素与心房颤动（AF）之间的关系仍不明确。在我们的研究中，我们比较了非瓣膜性房颤患者和对照组的血清胆红素水平。
材料与方法
我们的研究纳入了102例无任何其他心血管疾病的非瓣膜性慢性房颤患者（平均年龄62.51±5.88岁）。100例年龄匹配的窦性心律健康人作为对照组（平均年龄61.35±5.44岁）。检测了常规生化参数和血清胆红素水平。
结果
两组在基本特征方面未发现统计学显著差异。与对照组相比，房颤患者的血清总胆红素、直接胆红素和间接胆红素水平显著降低（分别为0.82±0.8 vs. 0.48±0.5、0.30±0.2 vs. 0.19±0.1和0.52±0.5 vs. 0.29±0.3mg/dL；所有P均<0.001）。
结论
因此，我们的研究揭示了血清胆红素与非瓣膜性房颤之间的关系。
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