微小RNA作为银屑病中的调控元件
MicroRNAs as regulatory elements in psoriasis.
作者信息
Liu Yuan, Liu Quanzhong
机构信息
Department of Dermatovenereology, Tianjin Medical University General Hospital, 154 Anshan Road, Heping District, Tianjin 300052, China.
出版信息
Open Med (Wars). 2016 Aug 12;11(1):336-340. doi: 10.1515/med-2016-0063. eCollection 2016.
Abstract
Psoriasis is a chronic, autoimmune, and complex genetic disorder that affects 23% of the European population. The symptoms of Psoriatic skin are inflammation, raised and scaly lesions. microRNA, which is short, nonprotein-coding, regulatory RNAs, plays critical roles in psoriasis. microRNA participates in nearly all biological processes, such as cell differentiation, development and metabolism. Recent researches reveal that multitudinous novel microRNAs have been identified in skin. Some of these substantial novel microRNAs play as a class of posttranscriptional gene regulator in skin disease, such as psoriasis. In order to insight into microRNAs biological functions and verify microRNAs biomarker, we review diverse references about characterization, profiling and subtype of microRNAs. Here we will share our opinions about how and which microRNAs are as regulatory in psoriasis.
摘要
银屑病是一种慢性、自身免疫性和复杂的遗传性疾病，影响着23%的欧洲人口。银屑病皮肤的症状是炎症、凸起和鳞状病变。微小RNA是短的、非蛋白质编码的调节性RNA，在银屑病中起关键作用。微小RNA几乎参与所有生物过程，如细胞分化、发育和代谢。最近的研究表明，在皮肤中已鉴定出众多新型微小RNA。其中一些重要的新型微小RNA在皮肤病（如银屑病）中作为一类转录后基因调节因子发挥作用。为了深入了解微小RNA的生物学功能并验证微小RNA生物标志物，我们查阅了有关微小RNA的表征、谱分析和亚型的各种参考文献。在此，我们将分享关于哪些微小RNA以及如何在银屑病中发挥调节作用的观点。
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