Human Genetics Unit, Indian Statistical Institute, 203 B T Road, Kolkata, 700 108, India.
Funct Integr Genomics. 2023 Apr 19;23(2):129. doi: 10.1007/s10142-023-01057-5.
Psoriasis is a complex genetic skin disorder typically manifested by red, scaly, and itchy plaques most commonly over the scalp, trunk, elbows, and knees. Histopathological features include thickening of the epidermal layer due to hyper-proliferation and abnormal differentiation of epidermal keratinocytes along with infiltration of immune cells in the psoriatic skin. It is a chronic inflammatory relapsing disease, and there is currently no permanent cure for psoriasis. Proper medications can reduce the severity of the disease and improve the quality of life of the patients. While the genetic components of psoriasis pathogenesis are well explored, the full understanding of its epigenetic component remains elusive. Non-coding RNAs (ncRNAs) are documented to regulate various epigenetic processes that lead to the pathogenesis of different diseases including psoriasis. In this review, we have discussed the molecular interplay of different ncRNAs in psoriasis pathogenesis. The roles of microRNAs (miRNAs) in psoriasis are pretty well studied, whereas the roles of long noncoding RNAs (lncRNAs) and circular RNAs (circRNAs) are emerging. This review provides ideas covering some of the latest findings of different modes of functions played by those different ncRNAs documented in the literature. As an ever-evolving topic, some works are still ongoing as well as there are several fields that need rigorous scientific ventures. We have proposed the areas which claim more explorations to better understand the roles played by the ncRNAs in psoriasis pathogenesis.
银屑病是一种复杂的遗传性皮肤疾病，通常表现为红色、鳞屑状和瘙痒斑块，最常见于头皮、躯干、肘部和膝盖。组织病理学特征包括表皮层因表皮角质形成细胞过度增殖和异常分化而增厚，以及银屑病皮肤中免疫细胞的浸润。它是一种慢性炎症性复发性疾病，目前尚无根治银屑病的方法。适当的药物可以减轻疾病的严重程度，提高患者的生活质量。虽然银屑病发病机制的遗传成分已经得到很好的研究，但对其表观遗传成分的全面理解仍然难以捉摸。非编码 RNA（ncRNA）被证明可以调节各种表观遗传过程，导致包括银屑病在内的不同疾病的发病。在这篇综述中，我们讨论了不同 ncRNA 在银屑病发病机制中的分子相互作用。miRNAs 在银屑病中的作用已经得到了很好的研究，而 lncRNAs 和 circRNAs 的作用正在出现。本综述提供了一些最新发现的不同模式的功能的想法，这些功能由文献中记录的不同 ncRNA 发挥。作为一个不断发展的主题，一些工作仍在进行中，也有几个领域需要严格的科学探索。我们提出了需要更多探索的领域，以更好地理解 ncRNA 在银屑病发病机制中的作用。
