通过NIS介导对含色氨酸肽进行合成后修饰。
Post-synthetic modification of tryptophan containing peptides via NIS mediation.
作者信息
Gu Chen-Xue, Bi Qing-Wei, Gao Chu-Kun, Wen Jian, Zhao Zhi-Gang, Chen Zili
机构信息
Department of Chemistry, Renmin University of China, Beijing 100872, China.
出版信息
Org Biomol Chem. 2017 Apr 18;15(16):3396-3400. doi: 10.1039/c7ob00329c.
PMID:28352912
Abstract
A new efficient method was developed to provide modified tryptophan peptides through NIS (N-iodosuccinimide) mediated N-selective coupling of a Trp unit with 1,2,3-triazoles, of which, the preliminary spectral properties were also studied.
摘要
开发了一种新的有效方法，通过N-碘代琥珀酰亚胺（NIS）介导的色氨酸单元与1,2,3-三唑的N-选择性偶联来提供修饰的色氨酸肽，并对其初步光谱性质进行了研究。
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