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儿童严重哮喘。

Severe Asthma in Children.

机构信息

Capital Allergy and Respiratory Disease Center, 5609 J Street, Suite C, Sacramento, CA, 95819, USA.

出版信息

Curr Allergy Asthma Rep. 2017 Apr;17(4):21. doi: 10.1007/s11882-017-0688-z.

DOI:10.1007/s11882-017-0688-z
PMID:28353215
Abstract

PURPOSE OF REVIEW

The aim of this study is to characterize, diagnose, evaluate, and treat severe childhood asthma.

RECENT FINDINGS

Understanding the occurrence of the physiologic and clinical presentations of childhood severe asthma, the treatment and response may be predicted by biomarkers, but the patient's response is highly variable. The onset of severe asthma occurs early and is primarily predicted by severity of viral infection and coexistence of the atopic state.

摘要

综述目的

本研究旨在对儿童重度哮喘的特点、诊断、评估和治疗进行描述。

最近的发现

通过生物标志物可以预测儿童重度哮喘的生理和临床表现、治疗反应和结果,但患者的反应具有高度变异性。重度哮喘的发病时间较早,主要由病毒感染的严重程度和特应状态的共存来预测。

相似文献

1
Severe Asthma in Children.儿童严重哮喘。
Curr Allergy Asthma Rep. 2017 Apr;17(4):21. doi: 10.1007/s11882-017-0688-z.
2
Management of severe asthma in children.儿童重度哮喘的管理
Aust Fam Physician. 2011 Jan-Feb;40(1-2):35-8.
3
[Management of acute asthma in the emergency room].[急诊室急性哮喘的管理]
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Guideline for the management of chronic asthma in children--2000 update. Allergy Society of South Africa Working Group.儿童慢性哮喘管理指南——2000年更新版。南非过敏协会工作组
S Afr Med J. 2000 May;90(5 Pt 2):524-8, 530, 532 passim.
5
Origins and treatment of airway inflammation in childhood asthma.儿童哮喘气道炎症的起源与治疗
Pediatr Pulmonol Suppl. 2001;21:17-25.
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Postgraduate course presentation. Infantile bronchial asthma.
J Allergy Clin Immunol. 1981 May;67(5):339-47. doi: 10.1016/0091-6749(81)90077-4.
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Novel severe wheezy young children phenotypes: boys atopic multiple-trigger and girls nonatopic uncontrolled wheeze.新型严重喘息婴幼儿表型:男孩特应性多触发和女孩非特应性未控制喘息。
J Allergy Clin Immunol. 2012 Jul;130(1):103-10.e8. doi: 10.1016/j.jaci.2012.02.041. Epub 2012 Apr 13.
8
Guidelines for severe uncontrolled asthma.重度难治性哮喘指南。
Arch Bronconeumol. 2015 May;51(5):235-46. doi: 10.1016/j.arbres.2014.12.007. Epub 2015 Feb 10.
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Precision medicine in childhood asthma.儿童哮喘的精准医学
Curr Opin Allergy Clin Immunol. 2019 Apr;19(2):141-147. doi: 10.1097/ACI.0000000000000517.
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Pharmacologic Therapies in Pulmonology and Allergy.肺病学与过敏学中的药物治疗
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引用本文的文献

1
Biologics to Treat Severe Asthma in Children and Adolescents: A Practical Update.治疗儿童和青少年重度哮喘的生物制剂:实用更新
Pediatr Allergy Immunol Pulmonol. 2020 Dec;33(4):168-176. doi: 10.1089/ped.2020.1212. Epub 2020 Nov 13.
2
Assessment of asthma control among different measures and evaluation of functional exercise capacity in children and adolescents with asthma.评估不同测量方法下哮喘的控制情况以及哮喘患儿和青少年的功能性运动能力。
J Bras Pneumol. 2020;46(3):e20190102. doi: 10.36416/1806-3756/e20190102. Epub 2020 Mar 13.
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Targeted Therapy for Severe Asthma in Children and Adolescents: Current and Future Perspectives.

本文引用的文献

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Distinguishing characteristics of difficult-to-control asthma in inner-city children and adolescents.市中心儿童和青少年中难治性哮喘的鉴别特征。
J Allergy Clin Immunol. 2016 Oct;138(4):1030-1041. doi: 10.1016/j.jaci.2016.06.059.
2
Early-Life Origins of Chronic Obstructive Pulmonary Disease.慢性阻塞性肺疾病的早期生活起源
N Engl J Med. 2016 Sep 1;375(9):871-8. doi: 10.1056/NEJMra1603287.
3
Inflammatory and Comorbid Features of Patients with Severe Asthma and Frequent Exacerbations.重度哮喘和频繁发作患者的炎症及共病特征
儿童和青少年重度哮喘的靶向治疗:现状和未来展望。
Paediatr Drugs. 2019 Aug;21(4):215-237. doi: 10.1007/s40272-019-00345-7.
Am J Respir Crit Care Med. 2017 Feb 1;195(3):302-313. doi: 10.1164/rccm.201602-0419OC.
4
Relationships among aeroallergen sensitization, peripheral blood eosinophils, and periostin in pediatric asthma development.变应原致敏、外周血嗜酸性粒细胞与骨膜蛋白在儿童哮喘发病中的关系。
J Allergy Clin Immunol. 2017 Mar;139(3):790-796. doi: 10.1016/j.jaci.2016.05.033. Epub 2016 Jul 5.
5
Long-Acting β-Agonist in Combination or Separate Inhaler as Step-Up Therapy for Children with Uncontrolled Asthma Receiving Inhaled Corticosteroids.长效β受体激动剂联合或单独使用吸入器作为接受吸入性糖皮质激素治疗但哮喘控制不佳儿童的升级治疗方案
J Allergy Clin Immunol Pract. 2017 Jan-Feb;5(1):99-106.e3. doi: 10.1016/j.jaip.2016.06.009. Epub 2016 Jul 13.
6
Patterns of Growth and Decline in Lung Function in Persistent Childhood Asthma.持续性儿童哮喘肺功能的生长与衰退模式
N Engl J Med. 2016 May 12;374(19):1842-1852. doi: 10.1056/NEJMoa1513737.
7
Periostin as a biomarker for the diagnosis of pediatric asthma.骨膜蛋白作为小儿哮喘诊断的生物标志物。
Pediatr Allergy Immunol. 2016 Aug;27(5):521-6. doi: 10.1111/pai.12575. Epub 2016 May 18.
8
Tiotropium add-on therapy in adolescents with moderate asthma: A 1-year randomized controlled trial.噻托溴铵附加疗法治疗青少年中度哮喘:一项为期 1 年的随机对照试验。
J Allergy Clin Immunol. 2016 Aug;138(2):441-450.e8. doi: 10.1016/j.jaci.2016.01.011. Epub 2016 Mar 5.
9
Severe Asthma in Children: Lessons Learned and Future Directions.儿童重症哮喘:经验教训与未来方向
J Allergy Clin Immunol Pract. 2016 Jan-Feb;4(1):11-9; quiz 20-1. doi: 10.1016/j.jaip.2015.10.008.
10
Role of local eosinophilopoietic processes in the development of airway eosinophilia in prednisone-dependent severe asthma.局部嗜酸性粒细胞生成过程在泼尼松依赖型重度哮喘气道嗜酸性粒细胞增多症发生中的作用
Clin Exp Allergy. 2016 Jun;46(6):793-802. doi: 10.1111/cea.12695.