Kim Sung Bum, Kim Kook Hyun, Kim Tae Nyeun, Heo Jun, Jung Min Kyu, Cho Chang Min, Lee Yoon Suk, Cho Kwang Bum, Lee Dong Wook, Han Ji Min, Kim Ho Gak, Kim Hyun Soo
Department of Internal Medicine, Yeungnam University College of Medicine Department of Internal Medicine, Kyungpook National University School of Medicine Department of Internal Medicine, Keimyung University School of Medicine Department of Internal Medicine, Catholic University of Daegu School of Medicine Department of Internal Medicine, Daegu Fatima Hospital, Daegu, Korea.
Medicine (Baltimore). 2017 Mar;96(13):e6477. doi: 10.1097/MD.0000000000006477.
The aim of this study was to evaluate sex difference in the prevalence and risk factors for asymptomatic cholelithiasis in Korean health screening examinees.Examinees who underwent examination through health promotion center at 5 hospitals of Daegu-Gyeongbuk province in 2014 were analyzed retrospectively. All examinees were checked for height, weight, waist circumference, and blood pressure, and underwent laboratory tests and abdominal ultrasound. Diagnosis of cholelithiasis was made by ultrasound.Of the total of 30,544 examinees, mean age was 47.3 ± 10.9 years and male to female ratio was 1.4:1. Asymptomatic cholelithiasis was diagnosed in 1268 examinees with overall prevalence of 4.2%. In age below 40 years, females showed higher prevalence of asymptomatic cholelithiasis than males (2.7% vs. 1.9%, P = 0.020), whereas prevalence of asymptomatic cholelithiasis was higher in males than females older than 50 years (6.2% vs. 5.1%, P = 0.012). Multiple logistic regression analysis revealed age (≥50 years), obesity, and high blood pressure as risk factors for asymptomatic cholelithiasis in males and age, obesity, hypertriglyceridemia, and chronic hepatitis B infection in females (P < 0.05).Overall prevalence of asymptomatic cholelithiasis was 4.2% in Korean health screening examinees. Females showed higher prevalence of asymptomatic cholelithiasis than males younger than 40 years, whereas it was higher in males older than 50 years. Age and obesity were risk factors for asymptomatic cholelithiasis in both sexes. Males had additional risk factors of high blood pressure and females had hypertriglyceridemia and chronic hepatitis B infection.
本研究旨在评估韩国健康筛查受检者中无症状胆结石的患病率及危险因素的性别差异。对2014年在大邱-庆北地区5家医院的健康促进中心接受检查的受检者进行回顾性分析。所有受检者均测量身高、体重、腰围和血压，并进行实验室检查及腹部超声检查。胆结石的诊断通过超声进行。
在总共30544名受检者中，平均年龄为47.3±10.9岁，男女比例为1.4:1。1268名受检者被诊断为无症状胆结石，总体患病率为4.2%。在40岁以下人群中，女性无症状胆结石的患病率高于男性（2.7%对1.9%，P=0.020），而在50岁以上人群中，男性无症状胆结石的患病率高于女性（6.2%对5.1%，P=0.012）。多因素逻辑回归分析显示，年龄（≥50岁）、肥胖和高血压是男性无症状胆结石的危险因素，而年龄、肥胖、高甘油三酯血症和慢性乙型肝炎感染是女性无症状胆结石的危险因素（P<0.05）。
韩国健康筛查受检者中无症状胆结石的总体患病率为4.2%。40岁以下女性无症状胆结石的患病率高于男性，而50岁以上男性的患病率更高。年龄和肥胖是男女无症状胆结石的危险因素。男性还有高血压这一额外危险因素，女性则有高甘油三酯血症和慢性乙型肝炎感染。
