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基于 MIP 的传感器:癌症生物标志物测定的有前途的新工具。

MIP-Based Sensors: Promising New Tools for Cancer Biomarker Determination.

机构信息

Department of Chemistry "Ugo Schiff", University of Florence, Via della Lastruccia 3, Sesto Fiorentino 50019, Italy.

出版信息

Sensors (Basel). 2017 Mar 29;17(4):718. doi: 10.3390/s17040718.

Abstract

Detecting cancer disease at an early stage is one of the most important issues for increasing the survival rate of patients. Cancer biomarker detection helps to provide a diagnosis before the disease becomes incurable in later stages. Biomarkers can also be used to evaluate the progression of therapies and surgery treatments. In recent years, molecularly imprinted polymer (MIP) based sensors have been intensely investigated as promising analytical devices in several fields, including clinical analysis, offering desired portability, fast response, specificity, and low cost. The aim of this review is to provide readers with an overview on recent important achievements in MIP-based sensors coupled to various transducers (e.g., electrochemical, optical, and piezoelectric) for the determination of cancer biomarkers by selected publications from 2012 to 2016.

摘要

早期发现癌症是提高患者生存率的最重要问题之一。癌症生物标志物检测有助于在疾病进入晚期无法治愈之前提供诊断。生物标志物还可用于评估治疗和手术治疗的进展情况。近年来,基于分子印迹聚合物(MIP)的传感器已被广泛研究,作为在多个领域(包括临床分析)中具有良好应用前景的分析设备,具有便携性、快速响应、特异性和低成本等优点。本文综述了 2012 年至 2016 年期间发表的部分相关文献,重点介绍了各种传感器(例如电化学、光学和压电)与基于 MIP 的传感器偶联在用于癌症生物标志物测定方面的最新重要进展。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/928b/5421678/d3ea8ccb077a/sensors-17-00718-g001.jpg

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