Department of Materials and Environmental Technology, Tallinn University of Technology, Ehitajate tee 5, 19086 Tallinn, Estonia.
Biosensors (Basel). 2024 Jan 30;14(2):71. doi: 10.3390/bios14020071.
Early-stage detection and diagnosis of diseases is essential to the prompt commencement of treatment regimens, curbing the spread of the disease, and improving human health. Thus, the accurate detection of disease biomarkers through the development of robust, sensitive, and selective diagnostic tools has remained cutting-edge scientific research for decades. Due to their merits of being selective, stable, simple, and having a low preparation cost, molecularly imprinted polymers (MIPs) are increasingly becoming artificial substitutes for natural receptors in the design of state-of-the-art sensing devices. While there are different MIP preparation approaches, electrochemical synthesis presents a unique and outstanding method for chemical sensing applications, allowing the direct formation of the polymer on the transducer as well as simplicity in tuning the film properties, thus accelerating the trend in the design of commercial MIP-based sensors. This review evaluates recent achievements in the applications of electrosynthesized MIP sensors for clinical analysis of disease biomarkers, identifying major trends and highlighting interesting perspectives on the realization of commercial MIP-endowed testing devices for rapid determination of prevailing diseases.
疾病的早期检测和诊断对于及时开始治疗方案、遏制疾病传播和改善人类健康至关重要。因此，通过开发强大、敏感和选择性的诊断工具来准确检测疾病生物标志物一直是前沿科学研究。由于分子印迹聚合物（MIPs）具有选择性、稳定性、简单性和低制备成本的优点，它们越来越成为设计最先进传感设备中天然受体的人工替代品。虽然有不同的 MIP 制备方法，但电化学合成在化学传感应用中提供了一种独特而出色的方法，允许聚合物直接在换能器上形成，并且可以简单地调整膜性能，从而加速了基于商业 MIP 传感器的设计趋势。本综述评估了电合成 MIP 传感器在疾病生物标志物临床分析中的应用的最新进展，确定了主要趋势，并强调了实现用于快速确定流行疾病的商业 MIP 检测设备的有趣观点。
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