Tournade M F, Lemerle J, Brunat-Mentigny M, Bachelot C, Roche H, Taboureau O, Olive D, Lejars O, Boilletot A, Demeocq F
Institut Gustave-Roussy, Villejuif, France.
J Clin Oncol. 1988 May;6(5):793-6. doi: 10.1200/JCO.1988.6.5.793.
Twenty-one patients with advanced Wilms' tumor entered a phase II study with high-dose ifosfamide (3 g/m2 over two days every 15 days). Mesna and hyperhydration were associated with minimal bladder toxicity. After two courses, five partial responses and six complete responses were observed. Ten patients did not respond. The median duration of response was 2 months (range, 1 to 7). Therapy was delayed because of leukopenia for 1 or 2 weeks in only three cases. Fever and infection were not observed. Seven patients presented with hematuria, three of whom were among the 17 patients coadministered mesna, which did not interfere with subsequent therapy.
21例晚期肾母细胞瘤患者进入一项II期研究，接受高剂量异环磷酰胺治疗（每15天分两天给予3 g/m²）。美司钠和水化治疗使膀胱毒性降至最低。两个疗程后，观察到5例部分缓解和6例完全缓解。10例患者无反应。缓解的中位持续时间为2个月（范围1至7个月）。仅3例患者因白细胞减少症使治疗延迟1或2周。未观察到发热和感染。7例患者出现血尿，其中3例在同时接受美司钠治疗的17例患者中，血尿未干扰后续治疗。
