从产生病毒糖蛋白gp50的细胞系中获得的传染性伪狂犬病病毒和单纯疱疹病毒产量降低。
Reduced yield of infectious pseudorabies virus and herpes simplex virus from cell lines producing viral glycoprotein gp50.
作者信息
Petrovskis E A, Meyer A L, Post L E
机构信息
Upjohn Company, Kalamazoo, Michigan 49007.
出版信息
J Virol. 1988 Jun;62(6):2196-9. doi: 10.1128/JVI.62.6.2196-2199.1988.
Abstract
Pseudorabies virus (PRV) glycoprotein gp50 is the homolog of herpes simplex virus (HSV) glycoprotein D. Several cell lines that constitutively synthesize gp50 were constructed. Vero cells, HeLa cells, and pig kidney (MVPK) cells that produce gp50 all gave reduced yields of PRV and HSV progeny viruses when compared with the parent cell line or the same cell line transfected to produce a different protein. The reduction in virus yield was greatest at low multiplicities of infection. The Vero and HeLa cells that produce gp50 showed an even greater reduction in HSV yield than in PRV yield. This phenomenon may be an example in a herpesvirus of the interference observed in retroviruses or cross-protection in plant virus systems.
摘要
伪狂犬病病毒（PRV）糖蛋白gp50是单纯疱疹病毒（HSV）糖蛋白D的同源物。构建了几种组成性合成gp50的细胞系。与亲本细胞系或转染产生不同蛋白质的同一细胞系相比，产生gp50的非洲绿猴肾（Vero）细胞、人宫颈癌细胞（HeLa）和猪肾（MVPK）细胞产生的PRV和HSV子代病毒产量均降低。在低感染复数时，病毒产量的降低最为显著。产生gp50的Vero细胞和HeLa细胞中HSV产量的降低比PRV产量的降低更为明显。这种现象可能是疱疹病毒中观察到的逆转录病毒干扰或植物病毒系统中交叉保护的一个例子。
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