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抗gD单克隆抗体可抑制1型单纯疱疹病毒诱导的细胞融合。

Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1.

作者信息

Noble A G, Lee G T, Sprague R, Parish M L, Spear P G

出版信息

Virology. 1983 Aug;129(1):218-24. doi: 10.1016/0042-6822(83)90409-9.

DOI:10.1016/0042-6822(83)90409-9
PMID:6310880
Abstract

Monoclonal antibodies directed against glycoprotein D of herpes simplex virus completely inhibited fusion of Vero cells infected with type 1 virus. In contrast, several monoclonal antibodies directed against other viral glycoproteins, including B, were ineffective or were only minimally inhibitory at the highest concentrations tested.

摘要

针对单纯疱疹病毒糖蛋白D的单克隆抗体完全抑制了感染1型病毒的Vero细胞的融合。相比之下，几种针对包括糖蛋白B在内的其他病毒糖蛋白的单克隆抗体在测试的最高浓度下无效或仅有轻微抑制作用。

相似文献

1
Anti-gD monoclonal antibodies inhibit cell fusion induced by herpes simplex virus type 1.抗gD单克隆抗体可抑制1型单纯疱疹病毒诱导的细胞融合。
Virology. 1983 Aug;129(1):218-24. doi: 10.1016/0042-6822(83)90409-9.
2
A role for herpes simplex virus type 1 glycoprotein E in induction of cell fusion.单纯疱疹病毒1型糖蛋白E在诱导细胞融合中的作用。
J Gen Virol. 1989 Aug;70 ( Pt 8):2157-62. doi: 10.1099/0022-1317-70-8-2157.
3
Directed selection of recombinant human monoclonal antibodies to herpes simplex virus glycoproteins from phage display libraries.从噬菌体展示文库中定向筛选针对单纯疱疹病毒糖蛋白的重组人单克隆抗体。
Proc Natl Acad Sci U S A. 1995 Jul 3;92(14):6439-43. doi: 10.1073/pnas.92.14.6439.
4
Viral and cellular factors that influence cell fusion induced by herpes simplex virus.影响单纯疱疹病毒诱导的细胞融合的病毒和细胞因子。
Virology. 1980 Dec;107(2):402-14. doi: 10.1016/0042-6822(80)90307-4.
5
Amino acid substitutions in glycoprotein D mediate the ability of fusion from without-positive herpes simplex virus type 1 strains to penetrate at 4 degrees and in the presence of soluble glycoprotein D.糖蛋白D中的氨基酸取代介导了1型单纯疱疹病毒无融合阳性毒株在4℃及存在可溶性糖蛋白D的情况下的穿透能力。
Intervirology. 1995;38(5):283-9. doi: 10.1159/000150452.
6
Herpes simplex virus glycoprotein gA/B: evidence that the infected Vero cell products comap and arise by proteolysis.单纯疱疹病毒糖蛋白gA/B：受感染的非洲绿猴肾细胞产物通过蛋白水解作用进行比较和产生的证据。
J Virol. 1982 Oct;44(1):88-97. doi: 10.1128/JVI.44.1.88-97.1982.
7
Inhibition of glycosylation of herpes simplex virus glycoproteins: identification of antigenic and immunogenic partially glycosylated glycopeptides on the cell surface membrane.单纯疱疹病毒糖蛋白糖基化的抑制：细胞表面膜上抗原性和免疫原性部分糖基化糖肽的鉴定
Virology. 1983 Apr 15;126(1):1-18. doi: 10.1016/0042-6822(83)90458-0.
8
Human natural killer cell recognition of herpes simplex virus type 1 glycoproteins: specificity analysis with the use of monoclonal antibodies and antigenic variants.人类自然杀伤细胞对1型单纯疱疹病毒糖蛋白的识别：使用单克隆抗体和抗原变体进行特异性分析。
J Immunol. 1984 Oct;133(4):2206-14.
9
Differential immunologic reactivity and processing of glycoproteins gA and gB of herpes simplex virus types 1 and 2 made in Vero and HEp-2 cells.在非洲绿猴肾细胞（Vero）和人喉表皮样癌细胞（HEp-2）中产生的1型和2型单纯疱疹病毒糖蛋白gA和gB的免疫反应性差异及加工过程。
Proc Natl Acad Sci U S A. 1981 Aug;78(8):5202-6. doi: 10.1073/pnas.78.8.5202.
10
Characterization of inhibitory action of concanamycins against herpes simplex virus.刀豆氨酸对单纯疱疹病毒抑制作用的表征
Antivir Chem Chemother. 2001 Jan;12(1):51-9. doi: 10.1177/095632020101200103.

引用本文的文献

1
Herpes simplex virus Membrane Fusion.单纯疱疹病毒膜融合
Adv Anat Embryol Cell Biol. 2017;223:29-47. doi: 10.1007/978-3-319-53168-7_2.
2
Monoclonal Antibodies to Different Components of the Human Cytomegalovirus (HCMV) Pentamer gH/gL/pUL128L and Trimer gH/gL/gO as well as Antibodies Elicited during Primary HCMV Infection Prevent Epithelial Cell Syncytium Formation.针对人巨细胞病毒（HCMV）五聚体gH/gL/pUL128L和三聚体gH/gL/gO不同组分的单克隆抗体以及原发性HCMV感染期间产生的抗体可预防上皮细胞合胞体形成。
J Virol. 2016 Jun 24;90(14):6216-6223. doi: 10.1128/JVI.00121-16. Print 2016 Jul 15.
3
Cell-to-cell spread of wild-type herpes simplex virus type 1, but not of syncytial strains, is mediated by the immunoglobulin-like receptors that mediate virion entry, nectin1 (PRR1/HveC/HIgR) and nectin2 (PRR2/HveB).
野生型单纯疱疹病毒1型而非合胞体菌株的细胞间传播是由介导病毒体进入的免疫球蛋白样受体nectin1（PRR1/HveC/HIgR）和nectin2（PRR2/HveB）介导的。
J Virol. 2000 Apr;74(8):3909-17. doi: 10.1128/jvi.74.8.3909-3917.2000.
4
Characterization of a type-common human recombinant monoclonal antibody to herpes simplex virus with high therapeutic potential.一种具有高治疗潜力的单纯疱疹病毒通用型人重组单克隆抗体的特性分析。
J Clin Microbiol. 1998 Nov;36(11):3198-204. doi: 10.1128/JCM.36.11.3198-3204.1998.
5
HveA (herpesvirus entry mediator A), a coreceptor for herpes simplex virus entry, also participates in virus-induced cell fusion.HveA（单纯疱疹病毒进入介导因子A）是单纯疱疹病毒进入的共受体，也参与病毒诱导的细胞融合。
J Virol. 1998 Jul;72(7):5802-10. doi: 10.1128/JVI.72.7.5802-5810.1998.
6
The glycoprotein D (US6) homolog is not essential for oncogenicity or horizontal transmission of Marek's disease virus.糖蛋白D（US6）同源物对于马立克氏病病毒的致癌性或水平传播并非必不可少。
J Virol. 1998 Mar;72(3):2548-53. doi: 10.1128/JVI.72.3.2548-2553.1998.
7
Two mutations in gB-1 and gD-1 of herpes simplex virus type 1 are involved in the "fusion from without" phenotype in different cell types.单纯疱疹病毒1型gB-1和gD-1中的两种突变在不同细胞类型中与“从外部融合”表型有关。
Virus Genes. 1996;13(3):221-8. doi: 10.1007/BF00366982.
8
Cross-linking of glycoprotein oligomers during herpes simplex virus type 1 entry.单纯疱疹病毒1型进入过程中糖蛋白寡聚体的交联
J Virol. 1996 Sep;70(9):6076-82. doi: 10.1128/JVI.70.9.6076-6082.1996.
9
Anti-idiotypic antibodies mimicking glycoprotein D of herpes simplex virus identify a cellular protein required for virus spread from cell to cell and virus-induced polykaryocytosis.模拟单纯疱疹病毒糖蛋白D的抗独特型抗体鉴定出病毒在细胞间传播及病毒诱导的多核细胞增多所必需的一种细胞蛋白。
Proc Natl Acad Sci U S A. 1996 Mar 5;93(5):1836-40. doi: 10.1073/pnas.93.5.1836.
10
Evidence for involvement of equine herpesvirus 1 glycoprotein B in cell-cell fusion.马疱疹病毒1型糖蛋白B参与细胞间融合的证据。
Arch Virol. 1996;141(1):167-75. doi: 10.1007/BF01718598.