Cetković S, Bosković B
Medical Department, Military Technical Institute, Belgrade, Yugoslavia.
J Pharmacol Methods. 1988 Mar;19(1):31-7. doi: 10.1016/0160-5402(88)90042-3.
Detoxification of soman (1,2,2'-trimethylpropyl methylphosphonofluoridate) in the liver was studied in the rat phrenic nerve-diaphragm preparation in situ. Contractions of diaphragm induced by electrical stimulation of the phrenic nerve were continuously recorded. Twitch height depression caused by soman was influenced by the route of application (portal or jugular vein) indicating its rate of detoxification in the liver. Pretreatment with phenobarbital reduced, whereas previous application of tri-O-cresyl phosphate (TOCP) enhanced, effectiveness of soman administered i.p. Possible mechanisms of detoxification and the features of the method are discussed.
在大鼠膈神经-膈肌原位制备模型中研究了肝脏对梭曼（1,2,2'-三甲基丙基甲基膦酰氟）的解毒作用。连续记录膈神经电刺激引起的膈肌收缩。梭曼引起的抽搐高度降低受给药途径（门静脉或颈静脉）影响，表明其在肝脏中的解毒速率。苯巴比妥预处理可降低腹腔注射梭曼的有效性，而先前应用磷酸三邻甲苯酯（TOCP）则可增强其有效性。文中讨论了解毒的可能机制及该方法的特点。
