Shilo L, Pomeranz A, Rathaus M, Weiss E, Bernheim J, Shenkman L
Department of Medicine C, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.
Life Sci. 1988;42(19):1855-9. doi: 10.1016/0024-3205(88)90024-0.
In view of the known interrelationships between renin, aldosterone, and atrial natriuretic peptide (ANP), we sought to examine whether there also exists an interaction between ANP and digoxin-like immunoreactive factor (DLIF). We therefore studied the effects of ANP administration on normal and salt-depleted rats, and measured the effects on blood pressure, urine output, glomerular filtration rate, sodium excretion, aldosterone, ACTH, and DLIF levels. ANP administration resulted in a significant elevation of sodium excretion and glomerular filtration rate and a fall in blood pressure. DLIF concentrations in plasma rose significantly, as did urinary DLIF excretion. ANP administration resulted in a fall in aldosterone as well as ACTH. These observations suggest that ANP has a direct inhibitory effect on ACTH secretion. Our findings support the concept of an interrelationship between ANP and DLIF.
鉴于肾素、醛固酮和心房利钠肽（ANP）之间已知的相互关系，我们试图研究ANP与洋地黄样免疫反应因子（DLIF）之间是否也存在相互作用。因此，我们研究了给正常和缺盐大鼠注射ANP的效果，并测量了对血压、尿量、肾小球滤过率、钠排泄、醛固酮、促肾上腺皮质激素（ACTH）和DLIF水平的影响。注射ANP导致钠排泄和肾小球滤过率显著升高，血压下降。血浆中DLIF浓度显著上升，尿中DLIF排泄量也上升。注射ANP导致醛固酮以及ACTH下降。这些观察结果表明，ANP对ACTH分泌有直接抑制作用。我们的研究结果支持ANP与DLIF之间存在相互关系的概念。
