Shilo L, Pomeranz A, Rathaus M, Bernheim J, Shenkman L
Department of Medicine C, Meir Hospital, Kfar Saba, Israel.
Life Sci. 1989;44(24):1867-70. doi: 10.1016/0024-3205(89)90304-4.
Digoxin-like immunoreactive factor (DLIF) is an endogenous natriuretic material which causes diuresis and natriuresis after salt or fluid loading and which may play a pathogenetic role in various hypertensive states. In order to study the cardiovascular effects of DLIF, we administered partially purified material (500 ng/kg) iv to normal rats. DLIF administration caused a significant rise in blood pressure, induced a brisk diuresis, and slowed the heart rate. In addition, DLIF protected against digitalis toxicity. While iv digoxin, 1 mg/kg, uniformly produced lethal arrhythmias, administration of DLIF 15 min prior to digoxin infusion consistently protected against arrhythmias. These findings support the theory that DLIF may play a role in hypertension. In addition, DLIF may compete with digoxin for cardiac receptors.
地高辛样免疫反应因子（DLIF）是一种内源性利钠物质，在盐负荷或液体负荷后可引起利尿和利钠，可能在各种高血压状态中发挥致病作用。为了研究DLIF对心血管的影响，我们给正常大鼠静脉注射部分纯化的物质（500 ng/kg）。注射DLIF后血压显著升高，引起快速利尿，并使心率减慢。此外，DLIF可预防洋地黄中毒。静脉注射1 mg/kg地高辛通常会产生致命性心律失常，而在注射地高辛前15分钟注射DLIF则始终能预防心律失常。这些发现支持了DLIF可能在高血压中起作用的理论。此外，DLIF可能与地高辛竞争心脏受体。
