Asgeirsdottir G A, Kjartansdottir I, Olafsdottir A S, Hreinsson J P, Hrafnkelsson H, Johannsson E, Björnsson E S
a Section of Gastroenterology and Hepatology and Radiology , National University Hospital of Iceland , Reykjavík , Iceland.
b Faculty of Medicine.
Scand J Gastroenterol. 2017 Jun-Jul;52(6-7):686-690. doi: 10.1080/00365521.2017.1304986. Epub 2017 Mar 30.
The prevalence of Helicobacter pylori (HP) infection is decreasing in the western world. The seroprevalence among 25-50-year-old Icelandic adults was recently shown to be 30-40%. Information on the seroprevalence in Nordic children is limited. We aimed at ascertaining the infection prevalence among healthy Icelandic children.
The infection status in stored frozen blood samples from two cross-sectional studies on the health of 7-9-year-old children (n = 125) and 16-18-year-old adolescents (n = 80) was determined by enzyme-linked immunosorbent assay (ELISA). Information on family demographics and GI symptoms was obtained by standardized questionnaires.
Overall, 3.4% (7/205) of the children were infected with H. pylori. The prevalence was 2.6% (5/190), missing data n = 3, among children with both parents born in a low prevalence country compared to 17% (2/12) among those with at least one parent born in a high prevalence area (p = .026). When at least one parent was born in a high prevalence country, the odds ratio for being H. pylori seropositive was 2.2 (95% CI, 1.02-54.67), when adjusted for the educational status of the mother. There was no significant association between H. pylori infection and gastrointestinal symptoms.
Prevalence of H. pylori infection in Iceland has become very low, suggesting a great reduction in transmission from older generations. There was an association between H. pylori infection and origin from high prevalence areas but not with gastrointestinal symptoms. The results mirror recent studies of children of Scandinavian ancestry.
在西方世界，幽门螺杆菌（HP）感染率正在下降。最近显示，25至50岁冰岛成年人的血清阳性率为30%-40%。关于北欧儿童血清阳性率的信息有限。我们旨在确定健康冰岛儿童中的感染率。
通过酶联免疫吸附测定（ELISA）确定了两项关于7至9岁儿童（n = 125）和16至18岁青少年（n = 80）健康状况的横断面研究中储存的冷冻血液样本的感染状况。通过标准化问卷获得了家庭人口统计学和胃肠道症状的信息。
总体而言，3.4%（7/205）的儿童感染了幽门螺杆菌。父母双方均出生在低感染率国家的儿童中，感染率为2.6%（5/190），缺失数据n = 3，而父母至少一方出生在高感染率地区的儿童中，感染率为17%（2/12）（p = 0.026）。当至少一方父母出生在高感染率国家时，在根据母亲的教育状况进行调整后，幽门螺杆菌血清阳性的比值比为2.2（95%可信区间，1.02-54.67）。幽门螺杆菌感染与胃肠道症状之间无显著关联。
冰岛幽门螺杆菌感染率已变得非常低，这表明来自老一代的传播大幅减少。幽门螺杆菌感染与高感染率地区的出身有关，但与胃肠道症状无关。这些结果反映了最近对斯堪的纳维亚血统儿童的研究。
