从顶部到底部：中期因子和多效生长因子作为免疫调节中的新兴参与者。
From top to bottom: midkine and pleiotrophin as emerging players in immune regulation.
作者信息
Sorrelle Noah, Dominguez Adrian T A, Brekken Rolf A
机构信息
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA; and.
Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center, Dallas, Texas, USA; and
出版信息
J Leukoc Biol. 2017 Aug;102(2):277-286. doi: 10.1189/jlb.3MR1116-475R. Epub 2017 Mar 29.
Abstract
Cytokines are pivotal in the generation and resolution of the inflammatory response. The midkine/pleiotrophin (MK/PTN) family of cytokines, composed of just two members, was discovered as heparin-binding neurite outgrowth-promoting factors. Since their discovery, expression of this cytokine family has been reported in a wide array of inflammatory diseases and cancer. In this minireview, we will discuss the emerging appreciation of the functions of the MK/PTN family in the immune system, which include promoting lymphocyte survival, sculpting myeloid cell phenotype, driving immune cell chemotaxis, and maintaining hematopoiesis.
摘要
细胞因子在炎症反应的产生和消退过程中起着关键作用。细胞因子中的中期因子/多效生长因子（MK/PTN）家族仅由两个成员组成，最初是作为肝素结合神经突生长促进因子被发现的。自发现以来，该细胞因子家族在多种炎症性疾病和癌症中均有表达。在本综述中，我们将探讨对MK/PTN家族在免疫系统中功能的新认识，这些功能包括促进淋巴细胞存活、塑造髓样细胞表型、驱动免疫细胞趋化以及维持造血作用。
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