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Anticancer drugs: All roads lead to EZH2 inhibition.

作者信息

Villanueva M Teresa

出版信息

Nat Rev Drug Discov. 2017 Mar 30;16(4):239. doi: 10.1038/nrd.2017.55.

DOI:10.1038/nrd.2017.55
PMID:28356595
Abstract
摘要

相似文献

1
Anticancer drugs: All roads lead to EZH2 inhibition.抗癌药物:条条大路通EZH2抑制。
Nat Rev Drug Discov. 2017 Mar 30;16(4):239. doi: 10.1038/nrd.2017.55.
2
Developing EZH2-Targeted Therapy for Lung Cancer.开发针对肺癌的EZH2靶向疗法。
Cancer Discov. 2016 Sep;6(9):949-52. doi: 10.1158/2159-8290.CD-16-0800.
3
Role of the EZH2 histone methyltransferase as a therapeutic target in cancer.EZH2 组蛋白甲基转移酶在癌症治疗靶点中的作用。
Pharmacol Ther. 2016 Sep;165:26-31. doi: 10.1016/j.pharmthera.2016.05.003. Epub 2016 May 11.
4
BET and EZH2 Inhibitors: Novel Approaches for Targeting Cancer.BET和EZH2抑制剂:靶向癌症的新方法。
Curr Oncol Rep. 2019 Feb 4;21(2):13. doi: 10.1007/s11912-019-0762-x.
5
EZH2 inhibitors: a patent review (2014-2016).EZH2抑制剂:专利综述(2014 - 2016年)
Expert Opin Ther Pat. 2017 Jul;27(7):797-813. doi: 10.1080/13543776.2017.1316976. Epub 2017 Apr 20.
6
Design and Synthesis of Pyridone-Containing 3,4-Dihydroisoquinoline-1(2H)-ones as a Novel Class of Enhancer of Zeste Homolog 2 (EZH2) Inhibitors.含吡啶酮的3,4-二氢异喹啉-1(2H)-酮的设计与合成:一类新型的增强子同源物2(EZH2)抑制剂
J Med Chem. 2016 Sep 22;59(18):8306-25. doi: 10.1021/acs.jmedchem.6b00515. Epub 2016 Sep 6.
7
Finding an easy way to harmonize: a review of advances in clinical research and combination strategies of EZH2 inhibitors.寻找一种简便的方法来协调:EZH2 抑制剂的临床研究进展和联合策略综述。
Clin Epigenetics. 2021 Mar 24;13(1):62. doi: 10.1186/s13148-021-01045-1.
8
Targeting EZH2 in cancer therapy.癌症治疗中靶向EZH2
Curr Opin Oncol. 2017 Sep;29(5):375-381. doi: 10.1097/CCO.0000000000000390.
9
Selective inhibition of EZH2 by ZLD1039 blocks H3K27 methylation and leads to potent anti-tumor activity in breast cancer.ZLD1039对EZH2的选择性抑制作用可阻断H3K27甲基化,并在乳腺癌中产生强大的抗肿瘤活性。
Sci Rep. 2016 Feb 12;6:20864. doi: 10.1038/srep20864.
10
Preclinical Evidence of Anti-Tumor Activity Induced by EZH2 Inhibition in Human Models of Synovial Sarcoma.EZH2抑制在滑膜肉瘤人源模型中诱导抗肿瘤活性的临床前证据
PLoS One. 2016 Jul 8;11(7):e0158888. doi: 10.1371/journal.pone.0158888. eCollection 2016.

引用本文的文献

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Epigenetic regulation of bladder cancer in the context of aging.衰老背景下膀胱癌的表观遗传调控
Front Pharmacol. 2025 Aug 21;16:1617452. doi: 10.3389/fphar.2025.1617452. eCollection 2025.
2
The long and short non-coding RNAs modulating EZH2 signaling in cancer.长链和短链非编码 RNA 调节癌症中的 EZH2 信号通路。
J Hematol Oncol. 2022 Mar 2;15(1):18. doi: 10.1186/s13045-022-01235-1.
3
BET-bromodomain and EZH2 inhibitor-treated chronic GVHD mice have blunted germinal centers with distinct transcriptomes.BET 溴结构域和 EZH2 抑制剂治疗的慢性移植物抗宿主病小鼠的生发中心受损,转录组特征明显。

本文引用的文献

1
EZH2 is a potential therapeutic target for H3K27M-mutant pediatric gliomas.EZH2 是 H3K27M 突变型小儿脑胶质瘤的潜在治疗靶点。
Nat Med. 2017 Apr;23(4):483-492. doi: 10.1038/nm.4293. Epub 2017 Feb 27.
2
Loss of tumor suppressor KDM6A amplifies PRC2-regulated transcriptional repression in bladder cancer and can be targeted through inhibition of EZH2.抑癌基因 KDM6A 的缺失可增强膀胱癌中 PRC2 调控的转录抑制,可通过抑制 EZH2 进行靶向治疗。
Sci Transl Med. 2017 Feb 22;9(378). doi: 10.1126/scitranslmed.aai8312.
Blood. 2022 May 12;139(19):2983-2997. doi: 10.1182/blood.2021014557.
4
Pharmacological inhibition of EZH2 by GSK126 decreases atherosclerosis by modulating foam cell formation and monocyte adhesion in apolipoprotein E-deficient mice.GSK126对EZH2的药理学抑制作用通过调节载脂蛋白E缺陷小鼠中的泡沫细胞形成和单核细胞黏附来减轻动脉粥样硬化。
Exp Ther Med. 2021 Aug;22(2):841. doi: 10.3892/etm.2021.10273. Epub 2021 Jun 6.
5
Targeting EZH2-mediated methylation of histone 3 inhibits proliferation of pediatric acute monocytic leukemia cells .靶向 EZH2 介导的组蛋白 3 甲基化抑制小儿急性单核细胞白血病细胞的增殖。
Cancer Biol Ther. 2021 Apr 3;22(4):333-344. doi: 10.1080/15384047.2021.1902913. Epub 2021 May 12.
6
The Role of Non-Coding RNAs in Uveal Melanoma.非编码RNA在葡萄膜黑色素瘤中的作用。
Cancers (Basel). 2020 Oct 12;12(10):2944. doi: 10.3390/cancers12102944.
7
lncRNA SNHG7 affects malignant tumor behaviors through downregulation of EZH2 in uveal melanoma cell lines.长链非编码RNA SNHG7通过下调葡萄膜黑色素瘤细胞系中的EZH2影响恶性肿瘤行为。
Oncol Lett. 2020 Feb;19(2):1505-1515. doi: 10.3892/ol.2019.11240. Epub 2019 Dec 23.
8
JARID2 and the PRC2 complex regulate skeletal muscle differentiation through regulation of canonical Wnt signaling.JARID2 和 PRC2 复合物通过调节经典 Wnt 信号通路调节骨骼肌分化。
Epigenetics Chromatin. 2018 Aug 17;11(1):46. doi: 10.1186/s13072-018-0217-x.
9
Identifying genes as potential prognostic indicators in patients with serous ovarian cancer resistant to carboplatin using integrated bioinformatics analysis.利用综合生物信息学分析鉴定对卡铂耐药的浆液性卵巢癌患者的潜在预后指标基因。
Oncol Rep. 2018 Jun;39(6):2653-2663. doi: 10.3892/or.2018.6383. Epub 2018 Apr 19.
10
Epigenetic regulation of HIV-1 latency: focus on polycomb group (PcG) proteins.HIV-1 潜伏期的表观遗传调控:重点关注多梳蛋白组(PcG)蛋白。
Clin Epigenetics. 2018 Feb 5;10:14. doi: 10.1186/s13148-018-0441-z. eCollection 2018.