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自体干细胞移植成功治疗与多发性骨髓瘤相关的C3肾小球病。

C3 glomerulopathy associated to multiple myeloma successfully treated by autologous stem cell transplant.

作者信息

Hamzi M A, Zniber A, Badaoui G E, Mahtat E, Alhamany Z, Bayahia R, Ouzeddoun N

机构信息

Department of Medicine, 5 Military Hospital, Guelmim, Morocco.

Department of Nephrology, Dialysis, Renal Transplantation, Faculty of Medicine and Pharmacy, Ibn Sina University Hospital, Rabat, Morocco.

出版信息

Indian J Nephrol. 2017 Mar-Apr;27(2):141-144. doi: 10.4103/0971-4065.181884.

DOI:10.4103/0971-4065.181884
PMID:28356669
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5358157/
Abstract

A 32-year-old male presented with advanced renal failure and nephrotic proteinuria due to lambda light chain multiple myeloma. Renal biopsy showed a proliferative glomerulonephritis with isolated C3 deposits. Renal recovery was obtained after chemotherapy and autologous stem cell transplant. We review previously described cases of C3 glomerulopathy associated with monoclonal gammopathy.

摘要

一名32岁男性因λ轻链多发性骨髓瘤出现晚期肾衰竭和肾病性蛋白尿。肾活检显示为伴有孤立性C3沉积的增殖性肾小球肾炎。化疗和自体干细胞移植后肾功能恢复。我们回顾了先前描述的与单克隆丙种球蛋白病相关的C3肾小球病病例。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5358157/d25c40e0d92b/IJN-27-141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5358157/9c09786c684b/IJN-27-141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5358157/d25c40e0d92b/IJN-27-141-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5358157/9c09786c684b/IJN-27-141-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/29b7/5358157/d25c40e0d92b/IJN-27-141-g002.jpg

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本文引用的文献

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2
C3 glomerulonephritis associated with monoclonal gammopathy: a case series.C3 肾小球肾炎伴单克隆丙种球蛋白血症：病例系列。
Am J Kidney Dis. 2013 Sep;62(3):506-14. doi: 10.1053/j.ajkd.2013.02.370. Epub 2013 Apr 26.
3
Acquired and genetic complement abnormalities play a critical role in dense deposit disease and other C3 glomerulopathies.
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Kidney Int. 2018 Jul;94(1):178-186. doi: 10.1016/j.kint.2018.01.037. Epub 2018 May 3.
获得性和遗传性补体异常在致密物沉积病和其他 C3 肾小球疾病中起着关键作用。
Kidney Int. 2012 Aug;82(4):454-64. doi: 10.1038/ki.2012.63. Epub 2012 Mar 28.
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