Kubo T, Hata H, Misu Y
Department of Pharmacology, Yokohama City University School of Medicine, Japan.
Naunyn Schmiedebergs Arch Pharmacol. 1988 Jan;337(1):122-4. doi: 10.1007/BF00169489.
The effects of intrathecal, intracisternal and intravenous injections of yohimbine (10 micrograms) on hypotensive and bradycardic responses to the alpha agonist guanabenz (10 micrograms/kg, i.v.) were studied in anesthetized rats. The depressor response to guanabenz was inhibited by intrathecal pretreatment with yohimbine, while this pretreatment did not affect the bradycardic response to guanabenz. Intracisternal pretreatment with yohimbine inhibited both cardiovascular responses to guanabenz, whereas intravenous pretreatment with yohimbine affected neither. Guanabenz (1 microgram) decreased blood pressure when injected intrathecally but did not affect it when injected intravenously. These results suggest that in rats spinal alpha adrenoceptors are involved in mediation of the hypotensive action of the alpha agonist guanabenz injected systemically.
在麻醉大鼠中，研究了鞘内、脑池内和静脉注射育亨宾（10微克）对α激动剂胍那苄（10微克/千克，静脉注射）引起的低血压和心动过缓反应的影响。鞘内预先注射育亨宾可抑制对胍那苄的降压反应，而这种预处理不影响对胍那苄的心动过缓反应。脑池内预先注射育亨宾可抑制对胍那苄的两种心血管反应，而静脉预先注射育亨宾则对两者均无影响。鞘内注射胍那苄（1微克）可降低血压，而静脉注射则无影响。这些结果表明，在大鼠中，脊髓α肾上腺素能受体参与介导全身注射α激动剂胍那苄的降压作用。
