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胆固醇氧化酶样蛋白（CHODL）在肝细胞癌中的表达影响肝癌细胞的侵袭和迁移。

Expression of CHODL in hepatocellular carcinoma affects invasion and migration of liver cancer cells.

作者信息

Huang Zejian, Zhang Ning, Li Wenda, Cao Jun, Zhang Lei, Chen Yajin

机构信息

Department of Hepatobiliary and Pancreatic Surgery, Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University, Guangzhou, Guangdong 510120, P.R. China.

Department of Gastroenterology and Hepatology, The First Affiliated Hospital of Sun Yat-Sen University, Guangzhou, Guangdong 510000, P.R. China.

出版信息

Oncol Lett. 2017 Feb;13(2):715-721. doi: 10.3892/ol.2016.5466. Epub 2016 Dec 6.

DOI:10.3892/ol.2016.5466
PMID:28356950
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5351393/
Abstract

Hepatocellular carcinoma (HCC) is the third leading cause of cancer-associated death. Due to rapid progression and metastasis, the long-term survival remains poor for most patients. Thus, it is important to discover and develop novel preventive strategies and therapeutic approaches for HCC. Recent data show that chondrolectin (CHODL) is commonly overexpressed in the majority of lung cancers, indicating a possible correlation between CHODL and metastasis of lung cancer cells. Our investigation shows that the expression of CHODL is significantly decreased in HCC clinical samples and in HCC cell lines. Overexpression of CHODL in SMMC7721 cells with a lentiviral vector increased SMMC7721 cell migration and invasion. Our findings establish for the first time an association between human CHODL and HCC metastasis.

摘要

肝细胞癌（HCC）是癌症相关死亡的第三大主要原因。由于其快速进展和转移，大多数患者的长期生存率仍然很低。因此，发现并开发针对HCC的新型预防策略和治疗方法非常重要。最近的数据表明，软骨凝集素（CHODL）在大多数肺癌中普遍过度表达，这表明CHODL与肺癌细胞转移之间可能存在关联。我们的研究表明，CHODL在HCC临床样本和HCC细胞系中的表达显著降低。用慢病毒载体在SMMC7721细胞中过表达CHODL可增加SMMC7721细胞的迁移和侵袭。我们的研究结果首次确立了人类CHODL与HCC转移之间的关联。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/f462a17718ec/ol-13-02-0715-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/89d785bcf857/ol-13-02-0715-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/d6beae3d2d90/ol-13-02-0715-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/72650800c130/ol-13-02-0715-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/b9d10a099a52/ol-13-02-0715-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/f462a17718ec/ol-13-02-0715-g04.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/89d785bcf857/ol-13-02-0715-g00.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/d6beae3d2d90/ol-13-02-0715-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/72650800c130/ol-13-02-0715-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/b9d10a099a52/ol-13-02-0715-g03.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/251a/5351393/f462a17718ec/ol-13-02-0715-g04.jpg

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Induction of tumor initiation is dependent on CD44s in c-Met⁺ hepatocellular carcinoma.在c-Met⁺肝细胞癌中，肿瘤起始的诱导依赖于CD44s。
Effects of sustained hyperprolactinemia in late gestation on the mammary parenchymal tissue transcriptome of gilts.
妊娠晚期持续高催乳素血症对母猪乳腺实质组织转录组的影响。
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Promoter Hypermethylation of CHODL Contributes to Carcinogenesis and Indicates Poor Survival in Patients with Early-stage Colorectal Cancer.CHODL基因启动子高甲基化促进肿瘤发生并提示早期结直肠癌患者预后不良。
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