Heffernan Kevin S, Patvardhan Eshan A, Karas Richard H, Kuvin Jeffrey T
Human Performance Laboratory, Department of Exercise Science, Syracuse University, Syracuse NY, USA.
Division of Cardiology and the Molecular Cardiology Research Institute, Tufts Medical Center, Boston MA, USA.
Cardiol Res. 2011 Oct;2(5):218-223. doi: 10.4021/cr92w. Epub 2011 Sep 20.
Vascular dysfunction is highly prevalent if not ubiquitous in patients with hypertension. We compared two different measures of vascular function obtained from digital volume waveforms with measures of ventricular-vascular load derived from 24-hour blood pressure (BP) recordings in patients with hypertension.
Digital pulsatile volume waveforms were captured via plethysmography (peripheral arterial tone, PAT) and used to derive augmentation index (a measure of ventricular-vascular coupling) and the pulse wave amplitude-reactive hyperemia index (a measure of microvascular reactivity). Ambulatory arterial stiffness index (AASI) and the BP variability ratio (BPVR) were derived from 24-hour ambulatory BP recordings.
There was a positive association between PAT-AIx and AASI (r = 0.52, P < 0.05). There was also a positive association between PAT-AIx and BPVR (r = 0.37, P < 0.05). PAT-AIx was not associated with PWA-RHI (r = -0.14, P > 0.05). PWA-RHI was not associated with AASI or BPVR (P > 0.05).
PAT-AIx is associated with ambulatory measures of vascular function and may offer clinical insight into vascular burden and cardiovascular disease risk in patients with hypertension independent of information obtained from PWA-RHI.
血管功能障碍在高血压患者中即使并非普遍存在也极为常见。我们比较了从数字容积波形获得的两种不同血管功能测量指标与从高血压患者24小时血压（BP）记录得出的心室 - 血管负荷测量指标。
通过体积描记法（外周动脉张力，PAT）获取数字搏动容积波形，并用于得出增强指数（一种心室 - 血管耦合测量指标）和脉搏波振幅 - 反应性充血指数（一种微血管反应性测量指标）。动态动脉僵硬度指数（AASI）和血压变异性比率（BPVR）从24小时动态血压记录中得出。
PAT - AIx与AASI之间存在正相关（r = 0.52，P < 0.05）。PAT - AIx与BPVR之间也存在正相关（r = 0.37，P < 0.05）。PAT - AIx与PWA - RHI无关（r = -0.14，P > 0.05）。PWA - RHI与AASI或BPVR无关（P > 0.05）。
PAT - AIx与血管功能的动态测量指标相关，并且可能为高血压患者的血管负担和心血管疾病风险提供独立于从PWA - RHI获得的信息的临床见解。
