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推进针对结核病的宿主导向疗法。

Advancing host-directed therapy for tuberculosis.

作者信息

Yang Chul-Su

机构信息

Department of Molecular and Life Science, Hanyang University, Ansan 15588, S. Korea. ; Department of Bio-nanotechnology, Hanyang University, Seoul, 04673, S. Korea.

出版信息

Microb Cell. 2017 Mar 2;4(3):105-107. doi: 10.15698/mic2017.03.565.

DOI:10.15698/mic2017.03.565
PMID:28357397
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5349197/
Abstract

Tuberculosis (TB) drug-development strategies, a wide range of candidate host-directed therapies (HDT)s-including new and repurposed drugs, biologics, and cellular therapies-have been proposed to accelerate eradication of infection and overcome the problems associated with current treatment regimens. By investigating the interaction between macrophages and the intracellular parasite (), we uncovered that infection-induced signaling pathways suggest possibilities for the development of novel therapeutic modalities for TB that target the intracellular signaling pathways permitting the replication of (MTB).

摘要

结核病（TB）药物研发策略方面，已经提出了一系列候选宿主导向疗法（HDT），包括新的和重新利用的药物、生物制剂以及细胞疗法，以加速根除感染并克服当前治疗方案相关的问题。通过研究巨噬细胞与细胞内寄生虫之间的相互作用，我们发现感染诱导的信号通路为开发针对允许结核分枝杆菌（MTB）复制的细胞内信号通路的新型结核病治疗方法提供了可能性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ce/5349197/ce84b2277611/mic-04-105-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ce/5349197/06451ddb9d90/mic-04-105-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ce/5349197/ce84b2277611/mic-04-105-g02.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ce/5349197/06451ddb9d90/mic-04-105-g01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/97ce/5349197/ce84b2277611/mic-04-105-g02.jpg

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