Szklarz Grzegorz, Adrjanowicz Karolina, Knapik-Kowalczuk Justyna, Jurkiewicz Karolina, Paluch Marian
Institute of Physics, University of Silesia, Ulica Uniwersytecka 4, 40-007 Katowice, Poland.
Phys Chem Chem Phys. 2017 Apr 12;19(15):9879-9888. doi: 10.1039/c7cp00823f.
In this work, we have performed a detailed investigation on the crystallization tendency of the modeled glass-forming pharmaceutical compound, fenofibrate. To do this, we have employed four different experimental techniques allowing following of the crystallization process. This has included dielectric spectroscopy, optical microscopy, X-ray diffraction and differential scanning calorimetry. From the crystallization kinetic studies carried out at atmospheric pressure, we have determined the temperature dependence of the crystal growth rate and the overall crystallization rate. It was found that the time scale of the molecular motions responsible for α-relaxation correlates much better with the crystal growth rate than with the overall crystallization rate. Experiments carried out under varying thermodynamic conditions while remaining on the same timescale of α-relaxation have demonstrated that the crystallization tendency of the supercooled fenofibrate significantly slows down with increasing pressure. Lastly, we have also shown that the thermodynamic history of reaching crystallization conditions has a substantial impact on its overall progress.
在这项工作中，我们对模拟的玻璃形成药物化合物非诺贝特的结晶倾向进行了详细研究。为此，我们采用了四种不同的实验技术来跟踪结晶过程。这包括介电谱、光学显微镜、X射线衍射和差示扫描量热法。通过在大气压下进行的结晶动力学研究，我们确定了晶体生长速率和整体结晶速率对温度的依赖性。结果发现，负责α弛豫的分子运动的时间尺度与晶体生长速率的相关性比与整体结晶速率的相关性要好得多。在保持相同α弛豫时间尺度的同时，在不同热力学条件下进行的实验表明，过冷非诺贝特的结晶倾向随着压力的增加而显著减慢。最后，我们还表明，达到结晶条件的热力学历史对其整体进程有重大影响。
