肥胖与衰老的分子联系：聚焦于脂肪蛋白53和视网膜母细胞瘤蛋白。
Molecular connections of obesity and aging: a focus on adipose protein 53 and retinoblastoma protein.
作者信息
Chu Dinh-Toi, Tao Yang
机构信息
Institute for Research and Development, Duy Tan University, K7/25 Quang Trung, Danang, Vietnam.
Faculty of Biology, Hanoi National University of Education, Hanoi, Vietnam.
出版信息
Biogerontology. 2017 Jun;18(3):321-332. doi: 10.1007/s10522-017-9698-4. Epub 2017 Mar 30.
Obesity is an induced health problem that human beings have been facing with non-optimal treatment so far. Humans are on average getting fatter with age, and obesity and aging interact each other to shorten lifetime and decrease life quality. Obesity also causes several aging related-disorders such as cancer, strokes, cardiovascular disease, high blood pressure and type 2 diabetes. So, the molecular connections between aging and obesity are promising targets for bio-medical researches and innovative therapies of many health problems. In this review, we discuss the findings of adipose p53 and Rb-two central molecular linkages between aging and obesity-on lipid metabolism and obesity.
肥胖是一个人为导致的健康问题，到目前为止人类一直面临着非最佳治疗方法。随着年龄增长，人类平均变得越来越胖，肥胖与衰老相互作用，缩短寿命并降低生活质量。肥胖还会引发多种与衰老相关的疾病，如癌症、中风、心血管疾病、高血压和2型糖尿病。因此，衰老与肥胖之间的分子联系是生物医学研究和许多健康问题创新疗法的有前景的靶点。在这篇综述中，我们讨论脂肪组织中的p53和Rb——衰老与肥胖之间两个核心分子联系——对脂质代谢和肥胖的研究结果。
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