Department of Chemistry, Indian Institute of Technology Madras , Chennai 600 036, Tamil Nadu, India.
Org Lett. 2017 Apr 7;19(7):1902-1905. doi: 10.1021/acs.orglett.7b00674. Epub 2017 Mar 30.
The unconventional nucleophilic reactivity of maleimides, innate electrophiles, has been realized under Ru(II)-catalysis such that exposure to electrophiles delivered products of C-H chalcogenation and amidation in good yields (up to 94%). This protocol features mild conditions and operational simplicity with broad substrate scope, uses an inexpensive and air-stable catalyst, and also represents the first example of Ru(II) catalyzed C-H selenylation of alkenes.
马来酰亚胺具有非传统的亲核反应性，是内源性的亲电试剂，在 Ru(II)催化下得以实现，与亲电试剂接触后可高产率（高达 94%）得到 C-H 硫代和酰胺化产物。该反应条件温和、操作简单、底物适用范围广，使用的催化剂廉价且稳定，空气中稳定，还代表了首例 Ru(II)催化的烯烃 C-H 硒化反应。
