用于正电子发射断层显像心肌灌注成像的F标记剂的研究进展

Research Progress on F-Labeled Agents for Imaging of Myocardial Perfusion with Positron Emission Tomography.

作者信息

Mou Tiantian, Zhang Xianzhong

机构信息

Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.

State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.

出版信息

Molecules. 2017 Mar 30;22(4):562. doi: 10.3390/molecules22040562.

Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of CAD. However, neither single-photon emission computed tomography nor positron emission tomography clinical MPI agents can absolutely satisfy the demands of clinical practice. In the past decades, tremendous developments happened in the field of F-labeled MPI tracers. This review summarizes the current state of F-labeled MPI tracers, basic research data of those tracers, and the future direction of MPI tracer research.