Mou Tiantian, Zhang Xianzhong
Department of Nuclear Medicine, Beijing Anzhen Hospital, Capital Medical University, Beijing 100029, China.
State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics & Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen 361102, China.
Molecules. 2017 Mar 30;22(4):562. doi: 10.3390/molecules22040562.
Coronary artery disease (CAD) is the leading cause of death in the world. Myocardial perfusion imaging (MPI) plays a significant role in non-invasive diagnosis and prognosis of CAD. However, neither single-photon emission computed tomography nor positron emission tomography clinical MPI agents can absolutely satisfy the demands of clinical practice. In the past decades, tremendous developments happened in the field of F-labeled MPI tracers. This review summarizes the current state of F-labeled MPI tracers, basic research data of those tracers, and the future direction of MPI tracer research.
冠状动脉疾病（CAD）是全球主要的死亡原因。心肌灌注成像（MPI）在CAD的无创诊断和预后评估中发挥着重要作用。然而，单光子发射计算机断层扫描和正电子发射断层扫描临床MPI剂都不能完全满足临床实践的需求。在过去几十年中，F标记的MPI示踪剂领域取得了巨大进展。本文综述了F标记的MPI示踪剂的现状、这些示踪剂的基础研究数据以及MPI示踪剂研究的未来方向。
