Gerasimov A M, Zakharov A S
Vopr Med Khim. 1988 Jan-Feb;34(1):112-5.
Non-enzymatic oxidation in alkaline media of homogentisinic acid, excreted with urine in alkaptonuria, involved free radical mechanism. The oxidative process was accompanied by production of superoxide anion O2- and required metal cations. Free radical destruction of cells and biopolymers via O2- or homogentisinic acid semiquinone appears to be one of pathogenetic mechanisms responsible for impairment of connective tissue structures in patients with alkaptonuria.
在碱性介质中，尿黑酸（在尿黑酸尿症中随尿液排出）的非酶氧化涉及自由基机制。氧化过程伴随着超氧阴离子O2-的产生，并且需要金属阳离子。通过O2-或尿黑酸半醌对细胞和生物聚合物的自由基破坏似乎是导致尿黑酸尿症患者结缔组织结构受损的发病机制之一。
