Kirillicheva G B, Sinilova N G, Tumanian M A
Vopr Med Khim. 1988 Jan-Feb;34(1):56-9.
All the immunostimulators studied, independently on their biological origin and chemical structure, decreased the 5-nucleotidase activity in macrophages of mice peritoneal exudate, thus indicating activation of these cells. The most distinct inhibition of the enzymatic activity in macrophages was induced by preparations of microbial origin. The decrease of the 5-nucleotidase activity in macrophages was observed in mice of CBA strain only after intraperitoneal administration of the preparations, while in non-linear animals--after subcutaneous or itraperitoneal injections.
所有研究的免疫刺激剂,无论其生物学来源和化学结构如何,均降低了小鼠腹腔渗出液巨噬细胞中的5-核苷酸酶活性,从而表明这些细胞被激活。微生物来源的制剂对巨噬细胞中酶活性的抑制作用最为明显。仅在腹腔注射制剂后,CBA品系小鼠的巨噬细胞中5-核苷酸酶活性才会降低,而在非品系动物中,皮下或腹腔注射后该活性也会降低。