Shah K V, Buscema J
Department of Immunology and Infectious Diseases, Johns Hopkins University, School of Hygiene and Public Health, Baltimore, Maryland 21205.
Annu Rev Med. 1988;39:371-9. doi: 10.1146/annurev.me.39.020188.002103.
Human papillomavirus (HPV) infections of the genital tract are widespread and often subclinical. Of about a dozen genital tract HPVs, types 16 and 18 are strongly associated with squamous cell carcinoma of the cervix and of other sites in the lower genital tract. In invasive cervical cancers, the viral genomes are often integrated into the cellular DNA and are transcriptionally active. These viruses, with additional cofactors, play a role in genital tract malignancies.
人乳头瘤病毒（HPV）引起的生殖道感染很普遍，且常为亚临床感染。在大约十二种生殖道HPV中，16型和18型与宫颈癌以及下生殖道其他部位的鳞状细胞癌密切相关。在浸润性宫颈癌中，病毒基因组常整合到细胞DNA中并具有转录活性。这些病毒与其他辅助因子一起，在生殖道恶性肿瘤中发挥作用。
